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Dynamic-Clamp pp 275-285 | Cite as

Using the Dynamic Clamp to Explore the Relationship Between Intrinsic Activity and Network Dynamics

  • Anne-Elise TobinEmail author
  • Rachel Grashow
  • Lamont S. Tang
  • Stefan R. Pulver
  • Eve Marder
Chapter
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 1)

Abstract

Our goal is to understand how neural network dynamics depend on the properties of the component neurons and their synaptic connections. To that end, we propose a novel method using the dynamic clamp to evaluate the intrinsic properties of isolated neurons that replaces conventional methods such as measuring input impedance. Secondly, we construct novel circuits using the dynamic clamp by electrically coupling pairs of pacemakers of rhythmically active pyloric networks from stomatogastric ganglia. We determine whether we can synchronize pacemakers with different intrinsic frequencies and how the coupled network frequency depends on the frequencies of the isolated pacemaker kernels.

Notes

Acknowledgments

This work was supported by NIH NS059255 (AET), NIH NS581102 (RGG), and NIH 46742 (EM).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Anne-Elise Tobin
    • 1
    Email author
  • Rachel Grashow
  • Lamont S. Tang
  • Stefan R. Pulver
  • Eve Marder
  1. 1.Volen Center and Biology DepartmentBrandeis UniversityWalthamUSA

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