Relationship Between Brain Tissue Haemodynamics, Oxygenation And Metabolism In The Healthy Human Adult Brain During Hyperoxia And Hypercapnea

  • Ilias Tachtsidis
  • Martin M. Tisdall
  • Terence S. Leung
  • Caroline Pritchard
  • Christopher E. Cooper
  • Martin Smith
  • Clare E. Elwell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)

Abstract

This study investigates the relationship between changes in brain tissue haemodynamics, oxygenation and oxidised cytochrome-c-oxidase ([oxCCO]) in the adult brain during hyperoxia and hypercapnea. 10 healthy volunteers were studied. We measured the mean blood flow velocity of the right middle cerebral artery (Vmca) with transcranial Doppler (TCD) and changes in concentrations of total haemoglobin ([HbT]=[HbO2]+[HHb]), haemoglobin difference ([Hbdiff]=[HbO2]-[HHb]) and [oxCCO] with broadband near-infrared spectroscopy (NIRS). We also measured the absolute tissue oxygenation index (TOI) using NIR spatially resolved spectroscopy. During hyperoxia there was an increase in TOI (2.33±0.29%), [Hbdiff] (4.57±1.27⎧M) and in the oxidation of [oxCCO] (0.09±0.12⎧M); but a reduction in Vmca (5.85±4.85%) and HbT (1.29±0.91⎧M). During hyperoxia there was a positive correlation between [oxCCO] and TOI and [Hbdiff] (r=0.83 and r=0.95) and a negative association between [oxCCO] and Vmca and [HbT] (r=-0.74 and r=-0.87). During hypercapnea there was an increase in TOI (2.76±2.16%), [Hbdiff] (7.36±2.64), [HbT] (2.61±2.7⎧M), Vmca (14.92±17.5%) and in the oxidation of [oxCCO] (0.25±0.17⎧M). Correlation analysis shows that there was association between [oxCCO] and TOI, [Hbdiff] and [HbT] (r=0.83, r=0.93 and r=0.82) but not with Vmca (r=0.33). We conclude that an increase in [oxCCO] was seen during both challenges and it was highly associated with brain tissue oxygenation.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ilias Tachtsidis
    • 1
  • Martin M. Tisdall
    • 2
  • Terence S. Leung
    • 1
  • Caroline Pritchard
    • 2
  • Christopher E. Cooper
    • 3
  • Martin Smith
    • 2
  • Clare E. Elwell
    • 1
  1. 1.Department of Medical Physics and Bioengineering Malet Place Engineering BuildingUniversity CollegeLondonUK
  2. 2.Department of Neuroanaesthesia and Neurocritical CareThe National Hospital for Neurology and NeurosurgeryQueen SquareUK
  3. 3.Department of Biological SciencesUniversity of EssexWivenhoe ParkUK

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