Prognostic Potential Of The Pretherapeutic Tumor Oxygenation Status

  • Peter Vaupel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 645)

Abstract

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a key factor of the tumor pathophysiome, since it can promote tumor progression and resistance to therapy. Independent of established prognostic parameters, such as clinical tumor stage, histology, histological grade and nodal status, hypoxia has been identified as an adverse prognostic factor for patient outcome. Studies of pretreatment tumor hypoxia involving direct assessment (polarographic oxygen tension measurements) have suggested a poor prognosis for patients with hypoxic tumors. These investigations indicate a worse disease-free survival for patients with hypoxic cancers of the uterine cervix or soft tissue sarcomas. In head & neck cancers, the studies suggest that pretherapeutic hypoxia is prognostic for survival and local control.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Peter Vaupel
    • 1
  1. 1.Institute of Physiology and PathophysiologyUniversity of MainzDuesbergweg 6Germany

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