Animal Models for Anxiety Disorders

Chapter

Abstract

Anxiety disorders are characterized by overwhelming anxiety or fear and are chronic and relentless if left untreated. Current available treatments for anxiety disorders are inadequate and some have severe side effects, thus warranting a better understanding of the etiology and mechanisms underlying anxiety and the development of anxiety disorders. In this chapter, the use of animal models to identify molecular and cellular circuitry that regulate fear or anxiety, and the influence of environment on the development of fear or anxiety, are discussed.

Abbreviations

ACTH

Adrenocorticotropin

CORT

Corticosterone

CRH

Corticotrophin-releasing hormone

CS

Conditioned stimulus

5-HT1A

Serotonin 1A receptor

LTP

Long-term potentiation

MAO-A

Monoamine oxidase A

PTSD

Post-traumatic stress disorder

SSRI

Serotonin reuptake inhibitors

US

Un-conditioned stimulus

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of Biopharmaceutical Sciences, Programs in Human Genetics and Biological SciencesUniversity of CaliforniaSan FranciscoUSA

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