New Trends in the Susceptibility to Melanoma

  • Nadem Soufir
  • Bernard Grandchamp
  • Nicole Basset-Seguin
Part of the Cancer Treatment and Research book series (CTAR, volume 146)

In contrast with cutaneous squamous cell carcinomas, the risk for development of melanoma does not appear to be greatly increased after solid organ transplantation, except for the rare case of donor-derived melanoma. The clinical aspects of melanoma in organ transplant recipients are discussed elsewhere, but it would seem that genetic susceptibility to melanoma is likely to be of similar relevance to the immunosuppressed individual as to the immunocompetent individual. Because the outcome of melanoma, particularly thicker melanomas, is worse after transplantation (Matin et al., in press), patients who come from melanoma-prone families or who have a history of multiple melanomas must be carefully counselled before transplantation. Extremely close skin surveillance and a low threshold for biopsy of melanocytic lesions would be advisable.


Melanoma Risk CDKN2A Gene Melanoma Case Oculocutaneous Albinism CDKN2A Mutation 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Nadem Soufir
    • 1
  • Bernard Grandchamp
    • 2
  • Nicole Basset-Seguin
    • 3
  1. 1.Department of DermatologyLaboratoire de Biochimie Hormonale et Génétique, IFR02, Hopital Bichat-Claude BernardParisFrance
  2. 2.Department de Biochemie Hormonale et Génétique, Hôpital BichatParisFrance
  3. 3.Department of DermatologyHôpital,Saint-Louis, Policlinique de dermatologieParisFrance

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