Molecular Mechanisms of Parasite Invasion pp 174-181

Part of the Subcellular Biochemistry book series (SCBI, volume 47)

Leishmania Invasion and Phagosome Biogenesis

Abstract

Whereas bacterial pathogens take over the control of their host cell actin cytoskeleton by delivering an array of protein effectors through specialized secretion systems, promastigotes of the protozoan parasite Leishmania donovani rely entirely upon a cell surface glycolipid to achieve this feat. Here, we review recent evidence that L. donovani promastigotes subvert host macrophage actin dynamics during the establishment of infection and we discuss the potential mechanisms involved.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.INRS-Institut Armand-FrappierLavalCanada

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