Role of Cytokines
Cytokines are small glycoproteins produced by a number of cell types, predominantly leukocytes, that regulate immunity, inflammation and hematopoiesis. They regulate a number of physiological and pathological functions including innate immunity, acquired immunity and a plethora of inflammatory responses. The discovery of cytokines was initiated in the 1950s, but the precise identification of their structure and function took many years. The original discoveries were those of IL-I, IFN and nerve growth factors (NGFs); however, these cytokines were purified and given their names years later. Elucidation of the precise physiological, pathological and pharmacological effects of some of the cytokines is still in progress. The modern techniques of molecular biology were principally responsible for their complete identification and as a consequence, several hundred cytokine proteins and genes have been identified, and the process still continues.
Cytokines are produced from...
KeywordsMast Cell Idiopathic Pulmonary Fibrosis Mononuclear Phagocyte Hairy Cell Leukemia Capillary Leak Syndrome
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