Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder

  • Hamid Mostafavi Abdolmaleky
  • Cassandra L. Smith
  • Jin-Rong Zhou
  • Sam Thiagalingam

Studies from several laboratories have provided convincing data to support the notion that altered DNA methylation in response to varying physiological and environmental conditions may play a critical role in the fine-tuning of gene expression. However, the establishment of abnormal gene promoter DNA methylation patterns resulting from environmental insults or dysfunctional genes of the DNA methylation machinery may destabilize the normal epigenetic modification of genes. This may affect the equilibrium in the differential gene expression patterns in the normal differentiated cells and tilt the balance toward the disease phenotype. The individuals with genetic susceptibility to specific diseases are likely to be more prone to abnormal DNA methylation. Thus, it is highly likely that the lack of a direct relationship between genotype and phenotype in major psychiatric disorders and the variability in the manifestation of diseases in individuals with identical genetic makeup could be derived from the changes in the DNA methylation patterns.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Hamid Mostafavi Abdolmaleky
    • 1
    • 2
    • 3
    • 4
  • Cassandra L. Smith
    • 1
  • Jin-Rong Zhou
    • 2
  • Sam Thiagalingam
    • 3
  1. 1.Biomedical Engineering DepartmentBoston UniversityBoston
  2. 2.Laboratory of Nutrition and Metabolism at BIDMC, Department of SurgeryHarvard Medical SchoolBoston
  3. 3.Departments of Medicine (Genetics Program), Genetics & Genomics, and Pathology & Laboratory MedicineBoston University School of MedicineBoston
  4. 4.Department of Psychiatry, Tehran Psychiatric Institute and Mental Health Research CenterIran University of Medical SciencesTehranIran

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