Investigation of Frontal Cortex, Motor Cortex and Systemic Haemodynamic Changes During Anagram Solving
We have previously reported changes in the concentrations of oxy- (δ[HbO2]) deoxy- (δ[HHb]) and total haemoglobin (δ[HbT]=δ[HbO2]+δ[HHb]) measured using near infrared spectroscopy (NIRS) over the frontal cortex (FC) during an anagram solving task. These changes were associated with a significant increase in both mean blood pressure (MBP) and heart rate (HR). The aim of this study was to investigate whether the changes in MBP previously recorded during an anagram solving task produces associated changes in scalp blood flow (flux) measured by laser Doppler and whether any changes are seen in NIRS haemodynamic measurements over a control region of the brain (motor cortex: MC). During the 4-Letter anagram task significant changes were observed in theδ[HbO2],δ[HHb] andδ[HbT] in both the frontal and motor cortex (n=11, FC p<0.01, MC p<0.01). These changes were accompanied by significant changes in both MBP (n=11, p<0.01) and scalp flux (n=9, p=0.01). During the 7-Letter anagram task significant changes were observed in the δ[HbO2] and δ[HbT] (n=11, FC p<0.01, MC p<0.01), which were accompanied by significant changes in both MBP (n=11, p=0.05) and flux (n=9, p=0.05). The task-related changes seen inMBP and flux in this study appear to contribute to the changes in the NIRS signals over both the activated and control regions of the cortex.
Unable to display preview. Download preview PDF.
- 4.A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Near Infrared Spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults, Neurosci. Lett. 154(1–2), 101–104 (14-5-1993).Google Scholar
- 8.I. Tachtsidis, T. S. Leung, L. Devoto, D. T. Delpy, and C. E. Elwell, Measurement of frontal lobe functional activation and related systemic effects: a near-infrared spectroscopy investigation., Adv. Exp. Med. Biol. (2007).Google Scholar
- 11.H. Kuwabara, K. Kasai, R. Takizawa, Y. Kawakubo, H. Yamasue, M. A. Rogers, M. Ishijima, K. Watanabe, and N. Kato, Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: A near-infrared spectroscopy study, Behav. Brain Res. 172(2), 272–277 (2006).PubMedCrossRefGoogle Scholar
- 13.J. Leon-Carrion, J. Damas, K. Izzetoglu, K. Pourrezai, J. F. Martin-Rodriguez, J. M. Martin, and M. R. Dominguez-Morales, Differential time course and intensity of PFC activation for men and women in response to emotional stimuli: a functional near-infrared spectroscopy (fNIRS) study, Neurosci. Lett. 403(1–2), 90–95 (2006).PubMedCrossRefGoogle Scholar