Toward a Higher Fidelity Model of AMD

  • Brian J. RaislerEmail author
  • Miho Nozaki
  • Judit Baffi
  • William W. Hauswirth
  • Jayakrishna Ambati
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Age-relatedmacular degeneration (AMD) is the leading cause of acquired blindness in the elderly population of industrialized countries (Klein et al., 1997; Vingerling et al., 1995; Leibowitz et al., 1980). Characterized clinically in two stages; ‘dry’ AMD consists of deposition of drusen under the RPE, particularly in the macular region, while ‘wet/exudative’ AMD consists of formation of new, invasive blood vessels originating from the choriodal vascular bed. Dry AMD can lead to vision loss due to geographic atrophy and photoreceptor loss, but most patients with drusen do not suffer loss of vision.


Choroidal Neovascularization Geographic Atrophy Gene Therapy Approach High Fidelity Model Cytoskeletal Disruption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Brian J. Raisler
    • 1
    Email author
  • Miho Nozaki
    • 2
  • Judit Baffi
    • 3
  • William W. Hauswirth
  • Jayakrishna Ambati
    • 4
  1. 1.Department of OphthalmologyUniversity of KentuckyLexington
  2. 2.Department of OphthalmologyUniversity of KentuckyLexington
  3. 3.Department of OphthalmologyUniversity of KentuckyLexington
  4. 4.Department of OphthalmologyUniversity of KentuckyLexington

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