The Relationship Between Periodontal Disease and Systemic Disease in the Elderly

  • Dana L. Wolf
  • Panos N. Papapanou


Oral Health Dental Plaque Tooth Loss Periodontal Treatment Periodontal Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Ajwani, S., Mattila, K. J., Tilvis, R. S. & Ainamo, A. (2003). Periodontal disease and mortality in an aged population. Special Care in Dentistry, 23, 125–130.PubMedGoogle Scholar
  2. Al-Zahrani, M. S., Bissada, N. F. & Borawskit, E. A. (2003). Obesity and periodontal disease in young, middle-aged, and older adults. Journal of Periodontology, 74, 610–615.PubMedGoogle Scholar
  3. Amar, S., Gokce, N., Morgan, S., Loukideli, M., Van Dyke, T. E. & Vita, J. A. (2003). Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 1245–1249.PubMedGoogle Scholar
  4. Arbes, S. J., Jr., Slade, G. D. & Beck, J. D. (1999). Association between extent of periodontal attachment loss and self-reported history of heart attack: an analysis of NHANES III data. Journal of Dental Research, 78, 1777–1782.PubMedGoogle Scholar
  5. Azarpazhooh, A. & Leake, J. L. (2006). Systematic review of the association between respiratory diseases and oral health. Journal of Periodontology, 77, 1465–1482.PubMedGoogle Scholar
  6. Baltch, A. L., Schaffer, C., Hammer, M. C., Sutphen, N. T., Smith, R. P., Conroy, J. & Shayegani, M. (1982). Bacteremia following dental cleaning in patients with and without penicillin prophylaxis. American Heart Journal, 104, 1335–1339.PubMedGoogle Scholar
  7. Bastard, J. P., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J. & Feve, B. (2006). Recent advances in the relationship between obesity, inflammation, and insulin resistance. European Cytokine Network, 17, 4–12.PubMedGoogle Scholar
  8. Bax, J. J., Inzucchi, S. E., Bonow, R. O., Schuijf, J. D., Freeman, M. R. & Barrett, E. (2007). Cardiac imaging for risk stratification in diabetes. Diabetes Care, 30(5), 1295–304.PubMedGoogle Scholar
  9. Beck, J. D., Eke, P., Heiss, G., Madianos, P., Couper, D., Lin, D., Moss, K., Elter, J. & Offenbacher, S. (2005a). Periodontal disease and coronary heart disease: a reappraisal of the exposure. Circulation, 112, 19–24.Google Scholar
  10. Beck, J. D., Eke, P., Lin, D., Madianos, P., Couper, D., Moss, K., Elter, J., Heiss, G. & Offenbacher, S. (2005b). Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults. Atherosclerosis, 183(2), 342–8.Google Scholar
  11. Beck, J. D., Elter, J. R., Heiss, G., Couper, D., Mauriello, S. M. & Offenbacher, S. (2001). Relationship of periodontal disease to carotid artery intima-media wall thickness: The atherosclerosis risk in communities (ARIC) study. Arteriosclerosis, Thrombosis, and Vascular Biology, 21, 1816–1822.PubMedGoogle Scholar
  12. Beltran-Aguilar, E. D., Barker, L. K., Canto, M. T., Dye, B. A., Gooch, B. F., Griffin, S. O., Hyman, J., Jaramillo, F., Kingman, A., Nowjack-Raymer, R., Selwitz, R. H. & Wu, T. (2005). Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis–United States, 1988–1994 and 1999–2002. MMWR Surveillance Summaries, 54,1–43.Google Scholar
  13. Bergmans, D. C., Bonten, M. J., Gaillard, C. A., Paling, J. C., van der Geest, S., van Tiel, F. H., Beysens, A. J., de Leeuw, P. W. & Stobberingh, E. E. (2001). Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study. American Journal of Respiratory and Critical Care Medicine, 164, 382–388.PubMedGoogle Scholar
  14. Borrell, L. N. & Papapanou, P. N. (2005). Analytical epidemiology of periodontitis. Journal of Clinical Periodontology, 32 Suppl 6, 132–158.Google Scholar
  15. Bretz, W. A., Weyant, R. J., Corby, P. M., Ren, D., Weissfeld, L., Kritchevsky, S. B., Harris, T., Kurella, M., Satterfield, S., Visser, M. & Newman, A. B. (2005). Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population. Journal of the American Geriatrics Society, 53, 1532–1537.PubMedGoogle Scholar
  16. Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K. & Deanfield, J. E. (1992). Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 340, 1111–1115.PubMedGoogle Scholar
  17. Christgau, M., Palitzsch, K.-D., Schmalz, G., Kreiner, U. & Frenzel, S. (1998). Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunological results. Journal of Clinical Periodontology, 25, 112–124.PubMedGoogle Scholar
  18. Cutler, C. W., Machen, R. L., Jotwani, R. & Iacopino, A. M. (1999). Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia. Journal of Periodontology, 70, 1313–1321.PubMedGoogle Scholar
  19. D’Aiuto, F., Nibali, L., Parkar, M., Suvan, J. & Tonetti, M. S. (2005). Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. Journal of Dental Research, 84, 269–273.PubMedGoogle Scholar
  20. D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D. & Tonetti, M. S. (2004a). Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers. Journal of Dental Research, 83,156–160.Google Scholar
  21. D’Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J. & Tonetti, M. S. (2006). Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart Journal, 151, 977–984.PubMedGoogle Scholar
  22. D’Aiuto, F., Ready, D. & Tonetti, M. S. (2004b). Periodontal disease and C-reactive protein-associated cardiovascular risk. Journal of Periodontal Research, 39, 236–241.Google Scholar
  23. Daly, C., Mitchell, D., Grossberg, D., Highfield, J. & Stewart, D. (1997). Bacteraemia caused by periodontal probing. Australian Dental Journal, 42, 77–80.PubMedGoogle Scholar
  24. de Ferranti, S. D. & Rifai, N. (2007). C-reactive protein: a nontraditional serum marker of cardiovascular risk. Cardiovascular Pathology, 16, 14–21.PubMedGoogle Scholar
  25. de Nardin, E. (2001). The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Annals of Periodontology, 6, 30–40.PubMedGoogle Scholar
  26. de Stefano, F., Anda, R. F., Kahn, H. S., Williamson, D. F. & Russell, C. M. (1993). Dental disease and risk of coronary heart disease and mortality [see comments]. British Medical Journal, 306, 688–691.Google Scholar
  27. Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Jr., Papapanou, P. N. & Sacco, R. L. (2003). Relationship between periodontal disease, tooth loss, and carotid artery plaque: The oral infections and vascular disease epidemiology study (INVEST). Stroke, 34, 2120–2125.PubMedGoogle Scholar
  28. Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Jr., Sacco, R. L. & Papapanou, P. N. (2005). Periodontal microbiota and carotid intima-media thickness: The oral infections and vascular disease epidemiology study (INVEST). Circulation, 111,576–582.PubMedGoogle Scholar
  29. Don, B. R. & Kaysen, G. (2004). Serum albumin: Relationship to inflammation and nutrition. Seminars in Dialysis, 17, 432–437.PubMedGoogle Scholar
  30. Ebersole, J. L., Machen, R. L., Steffen, M. J. & Willmann, D. E. (1997). Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clinical and Experimental Immunology 107, 347–352.PubMedGoogle Scholar
  31. Elter, J. R., Hinderliter, A. L., Offenbacher, S., Beck, J. D., Caughey, M., Brodala, N. & Madianos, P. N. (2006). The effects of periodontal therapy on vascular endothelial function: a pilot trial. American Heart Journal, 151, 47.e1–47.e6.Google Scholar
  32. Emrich, L. J., Shlossman, M. & Genco, R. J. (1991). Periodontal disease in non-insulin-dependent diabetes mellitus. Journal of Periodontology, 62, 123–131.PubMedGoogle Scholar
  33. Engebretson, S. P., Lamster, I. B., Elkind, M. S., Rundek, T., Serman, N. J., Demmer, R. T., Sacco, R. L., Papapanou, P. N. & Desvarieux, M. (2005). Radiographic measures of chronic periodontitis and carotid artery plaque. Stroke, 36(3), 561–6.PubMedGoogle Scholar
  34. Famili, P., Cauley, J., Suzuki, J. B. & Weyant, R. (2005). Longitudinal study of periodontal disease and edentulism with rates of bone loss in older women. Journal of Periodontology, 76, 11–15.PubMedGoogle Scholar
  35. Fiehn, N. E., Larsen, T., Christiansen, N., Holmstrup, P. & Schroeder, T. V. (2005). Identification of periodontal pathogens in atherosclerotic vessels. Journal of Periodontology, 76, 731–736.PubMedGoogle Scholar
  36. Forrester, J. S. & Bick-Forrester, J. (2005). Persistence of inflammatory cytokines cause a spectrum of chronic progressive diseases: Implications for therapy. Medical Hypotheses, 65, 227–231.PubMedGoogle Scholar
  37. Fourrier, F., Cau-Pottier, E., Boutigny, H., Roussel-Delvallez, M., Jourdain, M. & Chopin, C. (2000). Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients. Intensive Care Medicine, 26, 1239–1247.PubMedGoogle Scholar
  38. Fourrier, F., Dubois, D., Pronnier, P., Herbecq, P., Leroy, O., Desmettre, T., Pottier-Cau, E., Boutigny, H., Di Pompeo, C., Durocher, A. & Roussel-Delvallez, M. (2005). Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study. Critical Care Medicine, 33, 1728–1735.PubMedGoogle Scholar
  39. Fourrier, F., Duvivier, B., Boutigny, H., Roussel-Delvallez, M. & Chopin, C. (1998). Colonization of dental plaque: A source of nosocomial infections in intensive care unit patients. Critical Care Medicine, 26, 301–308.PubMedGoogle Scholar
  40. Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G. & McBurnie, M. A. (2001). Frailty in older adults: Evidence for a phenotype. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56, M146–M156.Google Scholar
  41. Genco, R. J., Grossi, S. G., Ho, A., Nishimura, F. & Murayama, Y. (2005). A proposed model linking inflammation to obesity, diabetes, and periodontal infections. Journal of Periodontology, 76, 2075–2084.PubMedGoogle Scholar
  42. Grossi, S. G., Genco, R. J., Machtei, E. E., Ho, A. W., Koch, G., Dunford, R., Zambon, J. J. & Hausmann, E. (1995). Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. Journal of Periodontology, 66, 23–29.PubMedGoogle Scholar
  43. Grossi, S. G., Skrepcinski, F. B., DeCaro, T., Robertson, D. C., Ho, A. W., Dunford, R. G. & Genco, R. J. (1997). Treatment of periodontal disease in diabetics reduces glycated hemoglobin. Journal of Periodontology, 68, 713–719.PubMedGoogle Scholar
  44. Haffajee, A. D. & Socransky, S. S. (1994). Microbial etiological agents of destructive periodontal diseases. Periodontology 2000, 5, 78–111.PubMedGoogle Scholar
  45. Hansson, G. K. (2005). Inflammation, atherosclerosis, and coronary artery disease. New England Journal of Medicine, 352, 1685–1695.PubMedGoogle Scholar
  46. Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M. & Genco, R. J. (2000). Identification of periodontal pathogens in atheromatous plaques. Journal of Periodontology, 71, 1554–1560.PubMedGoogle Scholar
  47. Huang, A. L. & Vita, J. A. (2006). Effects of systemic inflammation on endothelium-dependent vasodilation. Trends in Cardiovascular Medicine, 16, 15–20.PubMedGoogle Scholar
  48. Hujoel, P. P., White, B. A., Garcia, R. I. & Listgarten, M. A. (2001). The dentogingival epithelial surface area revisited. Journal of Periodontal Research, 36, 48–55.PubMedGoogle Scholar
  49. Janket, S. J., Wightman, A., Baird, A. E., Van Dyke, T. E. & Jones, J. A. (2005). Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. Journal of Dental Research, 84, 1154–1159.PubMedGoogle Scholar
  50. Jepsen, R. & Kuchel, G. A. (2006). Nutrition and inflammation: The missing link between periodontal disease and systemic health in the frail elderly? Journal of Clinical Periodontology, 33, 309–311.PubMedGoogle Scholar
  51. Joshipura, K. J., Willett, W. C. & Douglass, C. W. (1996). The impact of edentulousness on food and nutrient intake. Journal of the American Dental Association, 127, 459–467.PubMedGoogle Scholar
  52. Klemetti, E., Vainio, P., Lassila, V. & Alhava, E. (1993). Trabecular bone mineral density of mandible and alveolar height in postmenopausal women. Scandinavian Journal of Dental Research, 101, 166–170.PubMedGoogle Scholar
  53. Kornman, K. S., Page, R. C. & Tonetti, M. S. (1997). The host response to the microbial challenge in periodontitis: assembling the players. Periodontology 2000, 14, 33–53.PubMedGoogle Scholar
  54. Kozarov, E. V., Dorn, B. R., Shelburne, C. E., Dunn, W. A., Jr. & Progulske-Fox, A. (2005). Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arteriosclerosis, Thrombosis, and Vascular Biology, 25, e17–e18.Google Scholar
  55. Kribbs, P. J., Chesnut, C. H., Ott, S. M. & Kilcoyne, R. F. (1989). Relationships between mandibular and skeletal bone in an osteoporotic population. Journal of Prosthetic Dentistry, 62, 703–707.PubMedGoogle Scholar
  56. Kribbs, P. J., Chesnut, C. H., Ott, S. M. & Kilcoyne, R. F. (1990). Relationships between mandibular and skeletal bone in a population of normal women. Journal of Prosthetic Dentistry, 63,86–89.PubMedGoogle Scholar
  57. Kribbs, P. J., Smith, D. E. & Chesnut, C. H. (1983). Oral findings in osteoporosis. Part I: Measurement of mandibular bone density. Journal of Prosthetic Dentistry, 50, 576–579.PubMedGoogle Scholar
  58. Lalla, E., Lamster, I. B., Stern, D. M. & Schmidt, A. M. (2001). Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: Mechanisms and insights into therapeutic modalities. Annals of Periodontology, 6, 113–118.PubMedGoogle Scholar
  59. Lane, N. E. (2006). Epidemiology, etiology, and diagnosis of osteoporosis. American Journal of Obstetrics and Gynecology, 194, S3–S11.PubMedGoogle Scholar
  60. Langer, R. D., White, E., Lewis, C. E., Kotchen, J. M., Hendrix, S. L. & Trevisan, M. (2003). The Women’s Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures. Annals of Epidemiology, 13, S107–S121.PubMedGoogle Scholar
  61. Lee, H. J., Garcia, R. I., Janket, S. J., Jones, J. A., Mascarenhas, A. K., Scott, T. E. & Nunn, M. E. (2006). The association between cumulative periodontal disease and stroke history in older adults. Journal of Periodontology, 77, 1744–1754.PubMedGoogle Scholar
  62. Loesche, W. J., Schork, A., Terpenning, M. S., Chen, Y. M., Dominguez, B. L. & Grossman, N. (1998). Assessing the relationship between dental disease and coronary heart disease in elderly U.S. veterans. Journal of the American Dental Association, 129, 301–311.PubMedGoogle Scholar
  63. Loos, B. G. (2005). Systemic markers of inflammation in periodontitis. Journal of Periodontology, 76, 2106–2115.PubMedGoogle Scholar
  64. Ludewig, B., Krebs, P. & Scandella, E. (2004). Immunopathogenesis of atherosclerosis. Journal of Leukocyte Biology, 76, 300–306.PubMedGoogle Scholar
  65. Manolagas, S. C. (1995). Role of cytokines in bone resorption. Bone, 17, 63S-67S.PubMedGoogle Scholar
  66. Marsh, P. D. (2004). Dental plaque as a microbial biofilm. Caries Research, 38, 204–211.PubMedGoogle Scholar
  67. Mattila, K. J., Asikainen, S., Wolf, J., Jousimies-Somer, H., Valtonen, V. & Nieminen, M. (2000). Age, dental infections, and coronary heart disease. Journal of Dental Research, 79, 756–760.PubMedGoogle Scholar
  68. McGuinness, O. P. (2005). Defective glucose homeostasis during infection. Annual Review of Nutrition 25, 9–35.PubMedGoogle Scholar
  69. Meneilly (2006). Diabetes in the Elderly. Medical Clinics of North America, 90, 909–923.Google Scholar
  70. Mercanoglu, F., Oflaz, H., Oz, O., Gokbuget, A. Y., Genchellac, H., Sezer, M., Nisanci, Y. & Umman, S. (2004). Endothelial dysfunction in patients with chronic periodontitis and its improvement after initial periodontal therapy. Journal of Periodontology, 75, 1694–1700.PubMedGoogle Scholar
  71. Miller, L. S., Manwell, M. A., Newbold, D., Reding, M. E., Rasheed, A., Blodgett, J. & Kornman, K. S. (1992). The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases. Journal of Periodontology, 63, 843–848.PubMedGoogle Scholar
  72. Mohammad, A. R., Hooper, D. A., Vermilyea, S. G., Mariotti, A. & Preshaw, P. M. (2003). An investigation of the relationship between systemic bone density and clinical periodontal status in post-menopausal Asian-American women. International Dental Journal, 53, 121–125.PubMedGoogle Scholar
  73. Moller, D. E. (2000). Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends in Endocrinology and Metabolism, 11, 212–217.PubMedGoogle Scholar
  74. Nelson, R. G., Shlossman, M., Budding, L. M., Pettitt, D. J., Saad, M. F., Genco, R. J. & Knowler, W. C. (1990). Periodontal disease and NIDDM in Pima Indians. Diabetes Care, 13,836–840.PubMedGoogle Scholar
  75. Noack, B., Genco, R. J., Trevisan, M., Grossi, S., Zambon, J. J. & De Nardin, E. (2001). Periodontal infections contribute to elevated systemic C-reactive protein level. Journal of Periodontology, 72, 1221–1227.PubMedGoogle Scholar
  76. Norderyd, O. M., Grossi, S. G., Machtei, E. E., Zambon, J. J., Hausmann, E., Dunford, R. G. & Genco, R. J. (1993). Periodontal status of women taking postmenopausal estrogen supplementation. Journal of Periodontology, 64, 957–962.PubMedGoogle Scholar
  77. O’Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L. & Wolfson, S. K., Jr. (1999). Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. New England Journal of Medicine, 340, 14–22.PubMedGoogle Scholar
  78. Offenbacher, S. (1996). Periodontal diseases: Pathogenesis. Annals of Periodontology, 1, 821–878.PubMedGoogle Scholar
  79. Ogawa, H., Yoshihara, A., Amarasena, N., Hirotomi, T. & Miyazaki, H. (2006). Association between serum albumin and periodontal disease in community-dwelling elderly. Journal of Clinical Periodontology, 33, 312–316.PubMedGoogle Scholar
  80. Papapanou, P. N. (1996). Periodontal diseases: Epidemiology. Annals of Periodontology, 1, 1–36.PubMedGoogle Scholar
  81. Papapanou, P. N., Lindhe, J., Sterrett, J. D. & Eneroth, L. (1991). Considerations on the contribution of ageing to loss of periodontal tissue support. Journal of Clinical Periodontology, 18, 611–615.PubMedGoogle Scholar
  82. Pasceri, V. & Yeh, E. T. H. (1999). A Tale of Two Diseases: Atherosclerosis and Rheumatoid Arthritis. Circulation, 100, 2124–2126.PubMedGoogle Scholar
  83. Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., 3rd, Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., Rifai, N., Smith, S. C., Jr., Taubert, K., Tracy, R. P. & Vinicor, F. (2003). Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107, 499–511.PubMedGoogle Scholar
  84. Perry, H. M., 3rd (1999). The endocrinology of aging. Clinical Chemistry, 45, 1369–1376.PubMedGoogle Scholar
  85. Persson, R. E., Hollender, L. G., MacEntee, M. I., Wyatt, C. C. L., Kiyak, H. A. & Persson, G. R. (2003). Assessment of periodontal conditions and systemic disease in older subjects. Focus on diabetes mellitus. Journal of Clinical Periodontology, 30, 207–213.PubMedGoogle Scholar
  86. Phillips, A., Shaper, A. G. & Whincup, P. H. (1989). Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes. Lancet, 2, 1434–1436.PubMedGoogle Scholar
  87. Pihlstrom, B. L., Michalowicz, B. S. & Johnson, N. W. (2005). Periodontal diseases. Lancet, 366, 1809–1820.PubMedGoogle Scholar
  88. Promsudthi, A., Pimapansri, S., Deerochanawong, C. & Kanchanavasita, W. (2005). The effect of periodontal therapy on uncontrolled type 2 diabetes mellitus in older subjects. Oral Diseases, 11, 293–298.PubMedGoogle Scholar
  89. Ramadori, G. & Christ, B. (1999). Cytokines and the hepatic acute-phase response. Seminars in Liver Disease, 19, 141–155.PubMedGoogle Scholar
  90. Schmidt, R., Schmidt, H., Curb, J. D., et al. (2002). Early inflammation and dementia: A 25-year follow-up of the Honolulu-Asia aging study. Annals of Neurology, 52, 168–174.PubMedGoogle Scholar
  91. Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P. & Seeman, T. E. (2002). Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. Journal of the American Geriatrics Society, 50, 638–644.PubMedGoogle Scholar
  92. Ridker, P. M., Hennekens, C. H., Buring, J. E. & Rifai, N. (2000). C-Reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New England Journal of Medicine, 342, 836–843.PubMedGoogle Scholar
  93. Rothenbacher, D., Hoffmeister, A., Bode, G., Miller, M., Koenig, W. & Brenner, H. (2001). Helicobacter pylori heat shock protein 60 and risk of coronary heart disease: a case control study with focus on markers of systemic inflammation and lipids. Atherosclerosis, 156, 193–199.PubMedGoogle Scholar
  94. Saito, T., Shimazaki, Y., Koga, T., Tsuzuki, M. & Ohshima, A. (2001). Relationship between upper body obesity and periodontitis. Journal of Dental Research, 80, 1631–1636.PubMedGoogle Scholar
  95. Sanders, A. E., Slade, G. D., Carter, K. D. & Stewart, J. F. (2004). Trends in prevalence of complete tooth loss among Australians, 1979–2002. The Australian & New Zealand Journal of Public Health, 28, 549–554.Google Scholar
  96. Scannapieco, F. A. (1999). Role of oral bacteria in respiratory infection. Journal of Periodontology, 70, 793–802.PubMedGoogle Scholar
  97. Scannapieco, F. A., Bush, R. B. & Paju, S. (2003a). Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Annals of Periodontology, 8, 38–53.Google Scholar
  98. Scannapieco, F. A., Bush, R. B. & Paju, S. (2003b). Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review. Annals of Periodontology, 8, 54–69.Google Scholar
  99. Seinost, G., Wimmer, G., Skerget, M., Thaller, E., Brodmann, M., Gasser, R., Bratschko, R. O. & Pilger, E. (2005). Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis. American Heart Journal, 149, 1050–1054.PubMedGoogle Scholar
  100. Shay, K., Scannapieco, F. A., Terpenning, M. S., Smith, B. J. & Taylor, G. W. (2005). Nosocomial pneumonia and oral health. Special Care in Dentistry, 25, 179–187.PubMedGoogle Scholar
  101. Shultis, W. A., Weil, E. J., Looker, H. C., Curtis, J. M., Shlossman, M., Genco, R. J., Knowler, W. C. & Nelson, R. G. (2007). Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care, 30, 306–311.PubMedGoogle Scholar
  102. Silness, J. & Loee, H. (1964). Periodontal Disease in Pregnancy. Ii. Correlation between Oral Hygiene and Periodontal Condition. Acta Odontologica Scandinavica, 22, 121–135.PubMedGoogle Scholar
  103. Slade, G. D., Ghezzi, E. M., Heiss, G., Beck, J. D., Riche, E. & Offenbacher, S. (2003). Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study. Archives of Internal Medicine, 163, 1172–1179.PubMedGoogle Scholar
  104. Smith, B. J., Lerner, M. R., Bu, S. Y., Lucas, E. A., Hanas, J. S., Lightfoot, S. A., Postier, R. G., Bronze, M. S. & Brackett, D. J. (2006). Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation. Bone, 38, 378–386.PubMedGoogle Scholar
  105. Sopena, N., Sabria, M. & the Neunos Study, G. (2005). Multicenter Study of Hospital-Acquired Pneumonia in Non-ICU Patients. Chest, 127, 213–219.PubMedGoogle Scholar
  106. Stewart, J. E., Wager, K. A., Friedlander, A. H. & Zadeh, H. H. (2001). The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. Journal of Clinical Periodontology, 28, 306–310.PubMedGoogle Scholar
  107. Tabeta, K., Yamazaki, K., Hotokezaka, H., Yoshie, H. & Hara, K. (2000). Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients. Clinical and Experimental Immunology, 120, 285–293.PubMedGoogle Scholar
  108. Taylor, G. W., Burt, B. A., Becker, M. P., Genco, R. J. & Shlossman, M. (1998). Glycemic control and alveolar bone loss progression in type 2 diabetes. Annals of Periodontology, 3,30–39.PubMedGoogle Scholar
  109. Taylor, G. W., Burt, B. A., Becker, M. P., Genco, R. J., Shlossman, M., Knowler, W. C. & Pettitt, D. J. (1996). Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. Journal of Periodontology, 67, 1085–1093.PubMedGoogle Scholar
  110. Taylor, G. W., Loesche, W. J. & Terpenning, M. S. (2000). Impact of oral diseases on systemic health in the elderly: Diabetes mellitus and aspiration pneumonia. Journal of Public Health Dentistry, 60, 313–320.PubMedGoogle Scholar
  111. Terpenning, M. (2005). Geriatric oral health and pneumonia risk. Clinical Infectious Diseases, 40, 1807–1810.PubMedGoogle Scholar
  112. Terpenning, M., Bretz, W., Lopatin, D., Langmore, S., Dominguez, B. & Loesche, W. (1993). Bacterial colonization of saliva and plaque in the elderly. Clinical Infectious Diseases, 16 Suppl 4, S314–316.Google Scholar
  113. Terpenning, M. & Shay, K. (2002). Oral health is cost-effective to maintain but costly to ignore. Journal of the American Geriatrics Society, 50, 584–585.PubMedGoogle Scholar
  114. Terpenning, M. S., Taylor, G. W., Lopatin, D. E., Kerr, C. K., Dominguez, B. L. & Loesche, W. J. (2001). Aspiration pneumonia: dental and oral risk factors in an older veteran population. Journal of the American Geriatrics Society, 49, 557–563.PubMedGoogle Scholar
  115. Tervonen, T. & Karjalainen, K. (1997). Periodontal disease related to diabetic status. A pilot study of the response to periodontal therapy in type 1 diabetes. Journal of Clinical Periodontology, 24, 505–510.PubMedGoogle Scholar
  116. Tervonen, T. & Knuuttila, M. (1986). Relation of diabetes control to periodontal pocketing and alveolar bone level. Oral Surgery Oral Medicine Oral Pathology, 61, 346–349.Google Scholar
  117. Tervonen, T., Knuuttila, M., Pohjamo, L. & Nurkkala, H. (1991). Immediate response to nonsurgical periodontal treatment in subjects with diabetes mellitus. Journal of Clinical Periodontology, 18, 65–68.PubMedGoogle Scholar
  118. Theilade, E., Wright, W. H., Jensen, S. B. & Loe, H. (1966). Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation. Journal of Periodontal Research, 1,1–13.PubMedGoogle Scholar
  119. Tonetti, M. S., D’Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P. & Deanfield, J. (2007). Treatment of Periodontitis and Endothelial Function. New England Journal of Medicine, 356, 911–920.PubMedGoogle Scholar
  120. Tsai, C., Hayes, C. & Taylor, G. W. (2002). Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dentistry and Oral Epidemiology, 30, 182–192.PubMedGoogle Scholar
  121. UK Prospective Diabetes Study (UKPDS) Group (1998). Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). The Lancet, 352, 837–853.Google Scholar
  122. Verma, S., Buchanan, M. R. & Anderson, T. J. (2003). Endothelial function testing as a biomarker of vascular disease. Circulation, 108, 2054–2059.PubMedGoogle Scholar
  123. Verma, S., Devaraj, S. & Jialal, I. (2006). Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis. Circulation, 113, 2135–2150; discussion 2150.PubMedGoogle Scholar
  124. von Wowern, N., Klausen, B. & Olgaard, K. (1992). Steroid-induced mandibular bone loss in relation to marginal periodontal changes. Journal of Clinical Periodontology, 19, 182–186.Google Scholar
  125. Wactawski-Wende, J. (2001). Periodontal diseases and osteoporosis: Association and mechanisms. Annals of Periodontology, 6, 197–208.PubMedGoogle Scholar
  126. Wactawski-Wende, J., Hausmann, E., Hovey, K., Trevisan, M., Grossi, S. & Genco, R. J. (2005). The association between osteoporosis and alveolar crestal height in postmenopausal women. Journal of Periodontology, 76, 2116–2124.PubMedGoogle Scholar
  127. Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T. & Fried, L. P. (2006). Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. Journal of the American Geriatrics Society, 54, 991–1001.PubMedGoogle Scholar
  128. Weyant, R. J., Pearlstein, M. E., Churak, A. P., Forrest, K., Famili, P. & Cauley, J. A. (1999). The association between osteopenia and periodontal attachment loss in older women. Journal of Periodontology, 70, 982–991.PubMedGoogle Scholar
  129. Wilson, A. M., Ryan, M. C. & Boyle, A. J. (2006). The novel role of C-reactive protein in cardiovascular disease: Risk marker or pathogen. International Journal of Cardiology, 106, 291–297.PubMedGoogle Scholar
  130. Wu, T., Trevisan, M., Genco, R. J., Falkner, K. L., Dorn, J. P. & Sempos, C. T. (2000). Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. American Journal of Epidemiology, 151, 273–282.PubMedGoogle Scholar
  131. Yoneyama, T., Hashimoto, K., Fukuda, H., Ishida, M., Arai, H., Sekizawa, K., Yamaya, M. & Sasaki, H. (1996). Oral hygiene reduces respiratory infections in elderly bed-bound nursing home patients. Archives of Gerontology and Geriatrics, 22, 11–19.PubMedGoogle Scholar
  132. Yoneyama, T., Yoshida, M., Ohrui, T., Mukaiyama, H., Okamoto, H., Hoshiba, K., Ihara, S., Yanagisawa, S., Ariumi, S., Morita, T., Mizuno, Y., Ohsawa, T., Akagawa, Y., Hashimoto, K. & Sasaki, H. (2002). Oral care reduces pneumonia in older patients in nursing homes. Journal of the American Geriatrics Society, 50, 430–433.PubMedGoogle Scholar
  133. Yoshihara, A., Seida, Y., Hanada, N. & Miyazaki, H. (2004). A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults. Journal of Clinical Periodontology, 31, 680–684.PubMedGoogle Scholar
  134. Yoshihara, A., Watanabe, R., Nishimuta, M., Hanada, N. & Miyazaki, H. (2005). The relationship between dietary intake and the number of teeth in elderly Japanese subjects. Gerodontology, 22, 211–218.PubMedGoogle Scholar
  135. Yu, Y.-H. & Ginsberg, H. N. (2005). Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue. Circulation Research, 96, 1042–1052.PubMedGoogle Scholar
  136. Zampieri, S., Iaccarino, L., Ghirardello, A., Tarricone, E., Arienti, S., Sarzi-Puttini, P., Gambari, P. & Doria, A. (2005). Systemic Lupus Erythematosus, Atherosclerosis, and Autoantibodies. Annals of the New York Academy of Sciences, 1051, 351–361.PubMedGoogle Scholar
  137. Zebrack, J. S. & Anderson, J. L. (2002). The role of inflammation and infection in the pathogenesis and evolution of coronary artery disease. Current Cardiology Reports, 4, 278–288.PubMedGoogle Scholar
  138. Zielinski, M. B., Fedele, D., Forman, L. J. & Pomerantz, S. C. (2002). Oral health in the elderly with non-insulin-dependent diabetes mellitus. Special Care in Dentistry, 22, 94–98.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Dana L. Wolf
    • 1
  • Panos N. Papapanou
  1. 1.Division of Periodontics, Section of Oral and Diagnostic SciencesColumbia University College of Dental MedicineNew York

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