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The Evolution of Eukaryotic Cilia and Flagella as Motile and Sensory Organelles

  • David R. Mitchell
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 607)

Abstract

Eukaryotic cilia and flagella are motile organelles built on a scaffold of doublet microtubules and powered by dynein ATPase motors. Some thirty years ago, two competing views were presented to explain how the complex machinery of these motile organelles had evolved. Overwhelming evidence now refutes the hypothesis that they are the modified remnants of symbiotic spirochaete-like prokaryotes, and supports the hypothesis that they arose from a simpler cytoplasmic microtubule-based intracellular transport system. However, because intermediate stages in flagellar evolution have not been found in living eukaryotes, a clear understanding of their early evolution has been elusive. Recent progress in understanding phylogenetic relationships among present day eukaryotes and in sequence analysis of flagellar proteins have begun to provide a clearer picture of the origins of doublet and triplet microtubules, flagellar dynein motors, and the 9+2 microtubule architecture common to these organelles. We summarize evidence that the last common ancestor of all eukaryotic organisms possessed a 9+2 flagellum that was used for gliding motility along surfaces, beating motility to generate fluid flow, and localized distribution of sensory receptors, and trace possible earlier stages in the evolution of these characteristics.

Keywords

Basal Body Central Pair Curr Opin Cell Biol Eukaryotic Membrane Intraflagellar Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  1. 1.Department of Cell and Developmental BiologySUNY Upstate Medical UniversitySyracuseUSA

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