Targeted Therapies in Cancer pp 112-127

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 610)

Linking Inflammation Reactions to Cancer: Novel Targets for Therapeutic Strategies

  • Alberto Mantovani
  • Federica Marchesi
  • Chiara Porta
  • Paola Allavena
  • Antonio Sica

An inflammatory component is present in the microenvironment of most neoplastic tissues, including those not causally related to an obvious inflammatory process. Epidemiological studies have revealed that chronic inflammation predisposes to different forms of cancer and that usage of non-steroidal, anti-inflammatory agents is associated with protection against various tumors. The infiltration of white blood cells, the presence of polypeptide messengers of inflammation (cytokines and chemokines), the occurrence of tissue remodeling and angiogenesis, represent hallmarks of cancer-associated inflammation.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer 2008

Authors and Affiliations

  • Alberto Mantovani
    • 1
    • 2
  • Federica Marchesi
    • 1
  • Chiara Porta
    • 1
  • Paola Allavena
    • 1
  • Antonio Sica
    • 1
  1. 1.Istituto Clinico Humanitas IRCCSRozzano (Milan)Italy
  2. 2.Centro di Eccellenza per l'Innovazione Diagnostica e Terapeutica, Institute of PathologyUniversity of MilanItaly

Personalised recommendations