Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?

  • Christopher N. Wyatt
  • Selina A. Pearson
  • Prem Kumar
  • Chris Peers
  • D. Grahame Hardie
  • A. Mark Evans
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605)

The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.

Keywords

Carotid Body DU145 Cell Intermittent Hypoxia Mitochondrial Oxidative Phosphorylation Chronic Intermittent Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer 2008

Authors and Affiliations

  • Christopher N. Wyatt
    • 1
  • Selina A. Pearson
    • 2
  • Prem Kumar
    • 2
  • Chris Peers
    • 3
  • D. Grahame Hardie
    • 4
  • A. Mark Evans
    • 1
  1. 1.Division of Biomedical Sciences, School of BiologyUniversity of St AndrewsUK
  2. 2.Department of Physiology, The Medical SchoolUniversity of BirminghamUK
  3. 3.Department of MedicineUniversity of LeedsUK
  4. 4.Division of Molecular Physiology, School of Life SciencesUniversity of DundeeUK

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