Acute Neuronal Injury

pp 169-200


Programmed Neuronal Cell Death Mechanisms in CNS Injury

  • Bogdan A. StoicaAffiliated withDepartment of Neuroscience, Georgetown University Medical Center
  • , Alan I. FadenAffiliated withDepartment of Neuroscience, Georgetown University Medical Center Email author 

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Neuronal cell death is a critical physiological process necessary for the normal development of the CNS, as well as essential for removing dysfunctional cells after injury or other various pathological conditions. However, excessive or inappropriate neuronal cell loss is also a hallmark of acute or chronic neurodegeneration (Eldadah and Faden 2000; Snider et al. 1999; Graeber and Moran 2002; Honig and Rosenberg 2000). Many cell death effector pathways are common to both physiological and pathophysiological processes. Elucidating such mechanisms and initiating signals is essential for understanding neurodegeneration and designing effective therapies.