Programmed Neuronal Cell Death Mechanisms in CNS Injury

  • Bogdan A. Stoica
  • Alan I. FadenEmail author


Neuronal cell death is a critical physiological process necessary for the normal development of the CNS, as well as essential for removing dysfunctional cells after injury or other various pathological conditions. However, excessive or inappropriate neuronal cell loss is also a hallmark of acute or chronic neurodegeneration (Eldadah and Faden 2000; Snider et al. 1999; Graeber and Moran 2002; Honig and Rosenberg 2000). Many cell death effector pathways are common to both physiological and pathophysiological processes. Elucidating such mechanisms and initiating signals is essential for understanding neurodegeneration and designing effective therapies.


Cerebral Ischemia Neuronal Cell Death Central Nervous System Injury Mitochondrial Outer Membrane Permeabilization Cell Death Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of NeuroscienceGeorgetown University Medical CenterWashingtonUSA

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