Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment

  • James B. Knaak
  • Curt C. Dary
  • Miles S. Okino
  • Fred W. Power
  • Xiaofei Zhang
  • Carol B. Thompson
  • R. Tornero-Velez
  • Jerry N. Blancato
Chapter

Abstract

Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000).
Table 1

Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.a

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Copyright information

© Springer 2008

Authors and Affiliations

  • James B. Knaak
    • 1
  • Curt C. Dary
    • 2
  • Miles S. Okino
    • 2
  • Fred W. Power
    • 2
  • Xiaofei Zhang
    • 3
  • Carol B. Thompson
    • 3
  • R. Tornero-Velez
    • 4
  • Jerry N. Blancato
    • 4
  1. 1.Department of Pharmacology and Toxicology, School of Medicine and Biomedical SciencesSUNY at BuffaloBuffaloUSA
  2. 2.U.S. Environmental Protection AgencyHuman Exposure and Atmospheric Sciences DivisionLas VegasUSA
  3. 3.General Dynamics Information TechnologyHendersonUSA
  4. 4.U.S. Environmental Protection AgencyNational Exposure Research LaboratoryResearch Triangle ParkUSA

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