Invasion and Dissemination of Yersinia enterocolitica in the Mouse Infection Model

  • Konrad Trülzsch
  • Jürgen Heesemann
  • Mark F. Oellerich
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 603)

Yersinia enterocolitica is one of the most common causes of food borne gastrointestinal disease. After oral uptake yersiniae replicate in the small intestine, invade Peyeŕs patches of the distal ileum and disseminate to spleen and liver. In these tissues and organs yersiniae replicate extracellularly and form exclusively monoclonal microabscesses. Only very few yersiniae invade Peyeŕs patches and establish just a very few monoclonal microabscesses. This is due to both Yersinia and host specific factors.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

25.6 References

  1. Autenrieth, I.B., Vogel, U., Preger, S., Heymer, B. and Heesemann, J. (1993) Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response. Infect. Immun. 61, 2585-2595.PubMedGoogle Scholar
  2. Barnes, P.D., Bergman, M.A., Mecsas, J. and Isberg, R.R. (2006) Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J. Exp. Med. 203, 1591-1601.CrossRefPubMedGoogle Scholar
  3. Bottone, E.J. (1997) Yersinia enterocolitica: the charisma continues. Clin. Microbiol. Rev. 10, 257-276.PubMedGoogle Scholar
  4. Carter, P.B. (1975) Pathogenecity of Yersinia enterocolitica for mice. Infect. Immun. 11, 164-170.PubMedGoogle Scholar
  5. Clark, M.A., Hirst, B.H. and Jepson, M.A. (1998) M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer’s patch M cells. Infect. Immun. 66, 1237-1243.PubMedGoogle Scholar
  6. Clark, M.A. and Jepson, M.A. (2003) Intestinal M cells and their role in bacterial infection. Int. J. Med. Microbiol. 293, 17-39.CrossRefPubMedGoogle Scholar
  7. Conlan, J.W. (1997) Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia en-terocolitica. Infect. Immun. 65, 630-635.PubMedGoogle Scholar
  8. Eitel, J. and Dersch, P. (2002) The YadA protein of Yersinia pseudotuberculosis mediates high-efficiency uptake into human cells under environmental conditions in which invasin is repressed. Infect. Immun. 70, 4880-4891.CrossRefPubMedGoogle Scholar
  9. Grutzkau, A., Hanski, C., Hahn, H. and Riecken, E.O. (1990) Involvement of M cells in the bacterial invasion of Peyer’s patches: a common mechanism shared by Yersinia enterocoli-tica and other enteroinvasive bacteria. Gut 31, 1011-1015.CrossRefPubMedGoogle Scholar
  10. Hamburger, Z.A., Brown, M.S., Isberg, R.R. and Bjorkman, P.J. (1999) Crystal structure of invasin: a bacterial integrin-binding protein. Science 286, 291-295.CrossRefPubMedGoogle Scholar
  11. Handley, S.A., Newberry, R.D. and Miller, V.L. (2005) Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination. Infect. Im-mun. 73, 8453-8455.CrossRefGoogle Scholar
  12. Hanski, C., Kutschka, U, Schmoranzer, H.P., Naumann, M., Stallmach, A., Hahn, H., Menge, H. and Riecken, E.O. (1989) Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O8 with intestinal mucosa during experimental enteritis. Infect. Immun. 57, 673-678.PubMedGoogle Scholar
  13. Heesemann, J., Sing, A. and Trülzsch, K. (2006) Yersinia’s stratagem: targeting innate and adaptive immune defense. Curr. Opin. Microbiol 9, 55-61.CrossRefPubMedGoogle Scholar
  14. Heise, T. and Dersch, P. (2006) Identification of a domain in Yersinia virulence factor YadA that is crucial for extracellular matrix-specific cell adhesion and uptake. Proc. Natl. Acad. Sci. USA 103, 3375-3380.CrossRefPubMedGoogle Scholar
  15. Isberg, R.R. and Barnes, P. (2001) Subversion of integrins by enteropathogenic Yersinia. J. Cell. Sci. 114, 21-28.PubMedGoogle Scholar
  16. Isberg, R.R. and Leong, J.M. (1990) Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell 60, 861-871.CrossRefPubMedGoogle Scholar
  17. Leong, J.M., Fournier, R.S. and Isberg, R.R. (1990) Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. EMBO J. 9, 1979-1989.PubMedGoogle Scholar
  18. Marra, A. and Isberg, R.R. (1996) Analysis of the role of invasin during Yersinia pseudotu-berculosis infection of mice. Ann. N.Y. Acad. Sci. 797, 290-292.CrossRefPubMedGoogle Scholar
  19. Mecsas, J., Bilis, I. and Falkow, S. (2001) Identification of attenuated Yersinia pseudotubercu-losis strains and characterization of an orogastric infection in BALB/c mice on day 5 postinfection by signature-tagged mutagenesis. Infect. Immun. 69, 2779-2787.CrossRefPubMedGoogle Scholar
  20. Oellerich, M., Jacobi, C., Freund, S., Niedung, K., Bach, A., Heesemann, J. and Trülzsch, K. (2007) Yersinia enterocolitica infection of mice reveals clonal invasion and abscess for-mation. submitted for publication.Google Scholar
  21. Pepe, J.C., Badger, J.L. and Miller, V.L. (1994) Growth phase and low pH affect the thermal regulation of the Yersinia enterocolitica inv gene. Mol. Microbiol 11, 123-135.CrossRefPubMedGoogle Scholar
  22. Pepe, J.C. and Miller, V.L. (1993) Yersinia enterocolitica invasin: a primary role in the initia-tion of infection. Proc. Natl. Acad. Sci. USA 90,6473-6477.CrossRefPubMedGoogle Scholar
  23. Simonet, M., Richard, S. and Berche, P. (1990) Electron microscopic evidence for in vivo extracellular localization of Yersinia pseudotuberculosis harboring the pYV plasmid. In-fect. Immun. 58, 841-845.Google Scholar
  24. Trülzsch, K., Sporleder, T., Igwe, E.I., Russmann, H. and Heesemann, J. (2004) Contribution of the major secreted yops of Yersinia enterocolitica O:8 to pathogenicity in the mouse in-fection model. Infect. Immun. 72, 5227-5234.CrossRefPubMedGoogle Scholar
  25. Vazquez-Torres, A., Jones-Carson, J., Baumler, A.J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W.T. and Fang, F.C. (1999) Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature 401, 804-808.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Konrad Trülzsch
    • 1
  • Jürgen Heesemann
    • 1
  • Mark F. Oellerich
    • 1
  1. 1.Max von Pettenkofer Institute for Hygiene and Medical MicrobiologyLudwig Maximillians UniversityGermany

Personalised recommendations