The Genus Yersinia pp 192-200

Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 603)

Analysis of Yersinia pestis Gene Expression in the Flea Vector

  • Viveka Vadyvaloo
  • Florent Sebbane
  • B. Joseph Hinnebusch
  • Daniel Sturdevant
  • Clayton Jarrett

Yersinia pestis is the causative agent of plague. Unlike the other pathogenic Yersinia species, Y. pestis has evolved an arthropod-borne route of transmission, alternately infecting flea and mammalian hosts. Distinct subsets of genes are hypothesized to be differentially expressed during infection of the arthropod vector and mammalian host. Genes crucial for mammalian infection are referred to as virulence factors whilst genes playing a role in the flea vector are termed transmission factors. This article serves as a review of known factors involved in flea-borne transmission and introduces an ‘in vivo’ microarray approach to elucidating the genetic basis of Y. pestis infection of- and transmission by the flea.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Viveka Vadyvaloo
    • 1
  • Florent Sebbane
    • 2
  • B. Joseph Hinnebusch
    • 1
  • Daniel Sturdevant
    • 3
  • Clayton Jarrett
    • 1
  1. 1.Laboratory of Zoonotic PathogensNational Institutes of HealthHamiltonUSA
  2. 2.Institut Pasteur de LilleUniversité de Lille 2France
  3. 3.Research Technology Section, Rocky Mountain LaboratoriesNational Institutes of HealthHamiltonUSA

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