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Nanoparticles in Biomedical Imaging

Volume 102 of the series Fundamental Biomedical Technologies pp 413-425

Quantum Dots and Targeted Nanoparticle Probes for In Vivo Tumor Imaging

  • Matthew N. Rhyner
  • , Andrew M. Smith
  • , Xiaohu Gao
  • , Hui Mao
  • , Lily Yang
  • , Shuming Nie

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Abstract

Nanometer-sized particles, such as semiconductor quantum dots and iron oxide nanocrystals, have novel optical, electronic, magnetic, or structural properties that are not available from either individual molecules or bulk solids. When linked with tumor-targeting ligands, such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target tumor antigens (biomarkers) as well as tumor vasculatures with high affinity and specificity. In the “mesoscopic” size range of 5–100 nm diameter, quantum dots and related nanoparticles also have more surface areas and functional groups that can be linked to multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents. Previous research has led to the development of bioaffinity nanoparticle probes for advanced molecular and cellular imaging. In this chapter, we discuss recent advances in the development and applications of bioconjugated quantum dots and multifunctional nanoparticles for in vivo tumor imaging and targeting.

Keywords

quantum dot nanoparticle cancer imaging in vivo targeting polymer coating bimodal.