Control of Osteoclast Activity and Bone Loss by IKK Subunits: New Targets for Therapy

  • Maria Grazia Ruocco
  • Michael Karin
Part of the Advances in Experimental Medicine and Biology book series (volume 602)

Transcription factor NF-κB has been well recognized as a pivotal player in osteclastogenesis and inflammation-induced bone loss. Here, we discuss our recent results obtained using a genetic approach in mice that indicate the importance of IKKβ, and not IKKα, as a transducer of signals from receptor activator of NF-κB (RANK) to NF-κB. Ablation of IKKβ results in lack of osteoclastogenesis and unresponsiveness of IKKβ-deficient mice to inflammation-induced bone loss. In the need of a more effective therapy for the treatment of inflammatory diseases causing bone resorption, specific inhibition of IKKβ represents a logical alternative strategy to the current therapies.


Bone Loss Osteoclast Differentiation Bone Erosion Osteoclast Precursor IkappaB Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Maria Grazia Ruocco
    • 1
  • Michael Karin
    • 1
  1. 1.Laboratory of Gene Regulation and Signal TransductionUniversity of California, San DiegoLa JollaUSA

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