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GTPases in Semaphorin Signaling

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Semaphorins: Receptor and Intracellular Signaling Mechanisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 600))

Abstract

Ahallmark of semaphorin receptors is their interaction with multiple GTPases. Plexins, the signal transducing component of semaphorin receptors, directly associate with several GTPases. In addition, they not only recruit guaninine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) but also are the only known integral membrane proteins that show a catalytic activity as GAPs for small GTPases. GTPases function upstream of semaphorin receptors and regulate the activity of plexins through an interaction with the cytoplasmic domain. The association of Plexin-A1 (Sema3A receptor) or Plexin-B1 (Sema4D receptor) with the GTPase Rnd1 and ligand-dependent receptor clustering are required for their activity as R-Ras GAPs. The GTPases R-Ras and Rho function downstream of plexins and are required for the repulsive effects of semaphorins. In this review, I will focus on the role of GTPases in signaling by two plexins that have been analyzed in most detail, Plexin-A1 and Plexin-B1

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  1. Abteilung Molekularbiologie, Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität, Schloßplatz 5, 48149, Münster, Germany

    Andreas W. Püschel

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  1. Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

    R. J. Pasterkamp

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Püschel, A.W. (2007). GTPases in Semaphorin Signaling. In: Pasterkamp, R.J. (eds) Semaphorins: Receptor and Intracellular Signaling Mechanisms. Advances in Experimental Medicine and Biology, vol 600. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70956-7_2

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