TRAF Proteins in CD40 Signaling

  • Gail A. Bishop
  • Carissa R. Moore
  • Ping Xie
  • Laura L. Stunz
  • Zachary J. Kraus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)


The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.


CD40 Signaling Receptor Interact Protein CD40 Stimulation Tumor Necrosis Factor Receptor Associate Factor Early Lethality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Gail A. Bishop
    • 1
    • 2
  • Carissa R. Moore
  • Ping Xie
  • Laura L. Stunz
  • Zachary J. Kraus
  1. 1.Departments of Microbiology and Internal Medicine, Interdisciplinary Graduate Program in ImmunologyUniversity of IowaIowa CityUSA
  2. 2.Iowa City VAMCIowa CityUSA

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