TNF Receptor Associated Factors (TRAFs)

Volume 597 of the series Advances in Experimental Medicine and Biology pp 122-130

Molecular Basis for the Unique Specificity of TRAF6

  • Jee Y. Chung
  • , Miao Lu
  • , Qian Yin
  • , Su-Chang Lin
  • , Hao WuAffiliated withDepartment of Biochemistry, Weill Medical College of Cornell University

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Tumor necrosis factor (TNF) receptor (TNFR) associated factor 6 (TRAF6) is a unique member of the TRAF family of adaptor proteins that is involved in both the TNF receptor superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily signal transduction pathways. The ability to mediate signals from both families of receptors implicates TRAF6 as an important regulator of a diverse range of physiological processes such as innate and adaptive immunity, bone metabolism, and the development of lymph nodes, mammary glands, skin, and the central nervous system. This chapter will highlight the structural and biochemical studies of TRAF6 in receptor interactions and discuss the potential for peptidomimetic drug application based on TRAF6 receptor binding motif.