Blood Levels of Organochlorine Pesticide Residues and Risk of Reproductive Tract Cancer Among Women from Jaipur, India

  • Vibha Mathur
  • Placheril J. John
  • Inderpal Soni
  • Pradeep Bhatnagar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 617)


Residuesof organochlorine pesticides are integral part of our environment.Because of their strong lipophilic and non-biodegradable nature, organisms at higher trophic levels in the food chain tend to accumulate them. The aim of the present study was to assess the influence of organochlorine pesticides upon the occurrence of reproductive tract cancers in women from Jaipur, India. Blood samples were collected from 150 females. In that group, 100 females suffered from reproductive tract cancers like cervical, uterine, vaginal and ovarian cancers, while the rest did not suffer from cancers or any other major disease and were treated as control group. The collected blood samples were subjected to pesticide extraction and analyzed with the help of gas chromatography. The pesticides detected were benzene hexa chlororide and its isomers, dieldrin, heptachlor, dichloro diphenyl trichloro ethane and its metabolites. The data obtained indicate that the organochlorine pesticide residue levels were significantly higher in all the cancer patients as compared with the control group.


Estrogen Receptor Pesticide Residue Organochlorine Pesticide Dichloro Diphenyl Trichloro Ethane Clear Cell Adenocarcinoma 
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  1. 1.
    Falck F, Ricci A, Wolff MS, et al. (1992) Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 47:143–146.PubMedGoogle Scholar
  2. 2.
    Colborn T, Vom Saal FS, Sole AM (1993) Developmental Effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101:378–384.PubMedCrossRefGoogle Scholar
  3. 3.
    Turner KJ and Sharpe RM (1997) Environmental oestrogens – Present understanding. Rev Reprod 2:69–73.PubMedCrossRefGoogle Scholar
  4. 4.
    Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of maternal diethylstilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878–881.PubMedGoogle Scholar
  5. 5.
    Tiemann U, Schneider F, Tuchscherer A (1996). Effects of ornganochlorine pesticides on DNA synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers. Arch Toxicol 70:490–496.PubMedCrossRefGoogle Scholar
  6. 6.
    Arnold SF, Klotz DM, Collins BM, et al. (1996) Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272:1489–1492.PubMedCrossRefGoogle Scholar
  7. 7.
    Bush B, Snow J, Koblintz R (1984) Polychlorobiphenyl (PCB) congeners p,p'-DDE and hexachlorobenzene in maternal and fetal cord blood from mothrs inupstate. New York. Arch Environ Contam Toxicol 13:517–527.PubMedCrossRefGoogle Scholar
  8. 8.
    Agarwal, A (2000): Contaminated wheat. Down to Earth, Aug. 31. 22.Google Scholar
  9. 9.
    Nair A, Pillai MKK (1992) Trends in ambient levels of DDT and HCH residues in human and the environment of Delhi, India. The Sci Total Environ 121:145–157.CrossRefGoogle Scholar
  10. 10.
    Patlak M (1996) Estrogens may link pesticides. Breast Cancer Environ Sci Tech News 30(5):210A–211A.Google Scholar
  11. 11.
    Davis DL, Bradlow HL, Wolff M, et al. Medical hypothesis: Xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 101(5):372.Google Scholar
  12. 12.
    Golden RJ, Noller KL, Ernstoff LT, et al. (1998) Environmental endocrine modualators and human health: an Assessment of the biological evidence. Crit Rev Toxicol 28(2):109–227.PubMedCrossRefGoogle Scholar
  13. 13.
    Harris JR, Lippman ME, Veronesi V (1992). Breast cancer, Part 1 of 3, New Eng J Med 319–327.Google Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Vibha Mathur
  • Placheril J. John
    • 1
  • Inderpal Soni
  • Pradeep Bhatnagar
  1. 1.Department of ZoologyUniversity of RajasthanJaipurIndia

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