Ovarian Carcinogenesis: An Alternative Hypothesis

  • Jurgen M. J. Piek
  • Paul J. van Diest
  • René H. M. Verheijen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 622)

Cancer of the ovary is among the most common female genital tract cancers and has the worst prognosis. This is largely caused by the fact that these cancers are detected at late stage of disease, because of absence of early clinical symptoms. Consequently, early events in ovarian carcinogenesis remain remarkably unknown. Therefore, the precursor cell of these tumours remains a matter of debate (1, 2).

Three explanations as to the origin of serous ovarian adenocarcinomas have been put forward. The first one points towards the ovarian surface epithelium (OSE) as tissue of origin (3). Second, remnants of the embryologic Müllerian duct, the secondary Müllerian system, have been suggested as possible tissue of origin (4). The third is the Fallopian tube inner surface epithelium (TSE) (=oviduct epithelium) (1, 5). In this chapter, the third possible origin is highlighted.


Ovarian Carcinoma Fallopian Tube Ovarian Surface Epithelium Preneoplastic Lesion Inclusion Cyst 
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Copyright information

© Springer 2008

Authors and Affiliations

  • Jurgen M. J. Piek
    • 1
  • Paul J. van Diest
    • 2
  • René H. M. Verheijen
    • 3
  1. 1.Department of Obstetrics and GynaecologyVU University Medical CenterAmsterdamThe Netherlands
  2. 2.Department of PathologyUniversity Medical Center UtrechtUtrechtThe Netherlands
  3. 3.Department of Obstetrics and GynaecologyUniversity Medical Center UtrechtUtrechtThe Netherlands

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