MicroRNA in Human Cancer: One Step Forward in Diagnosis and Treatment
Cancer is a disease involving multistep dynamic changes in the genome. However, studies to date on the cancer genome have focused most heavily on protein-coding genes, and our knowledge on alterations of the functional noncoding sequences in cancer is largely absent. MicroRNAs (miRNAs) are ~22 nucleotide (nt) noncoding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Mounting evidence shows that miRNAs may play an important role in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.
KeywordsChronic Lymphocytic Leukemia Papillary Thyroid Carcinoma miRNA Expression miRNA Gene Copy Number Alteration
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