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MicroRNA in Human Cancer: One Step Forward in Diagnosis and Treatment

  • Lin Zhang
  • Nuo Yang
  • George Coukos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 622)

Cancer is a disease involving multistep dynamic changes in the genome. However, studies to date on the cancer genome have focused most heavily on protein-coding genes, and our knowledge on alterations of the functional noncoding sequences in cancer is largely absent. MicroRNAs (miRNAs) are ~22 nucleotide (nt) noncoding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Mounting evidence shows that miRNAs may play an important role in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.

Keywords

Chronic Lymphocytic Leukemia Papillary Thyroid Carcinoma miRNA Expression miRNA Gene Copy Number Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Lin Zhang
  • Nuo Yang
  • George Coukos
    • 1
  1. 1.Center for Research on the Early Detection and Cure of Ovarian CancerUniversity of PennsylvaniaPhiladelphia

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