The Contribution of the Neural Crest to the Vertebrate Body

  • Elisabeth Dupin
  • Sophie Creuzet
  • Nicole M. Le Douarin

Abstract

As a transitory structure providing adult tissues of the vertebrates with very diverse cell types, the neural crest (NC) has attracted for long the interest of developmental biologists and is still the subject of ongoing research in a variety of animal models. Here we review a number of data from in vivo cell tracing and in vitro single cell culture experiments, which gained new insights on the mechanisms of cell migration, proliferation and differentiation during NC ontogeny. We put emphasis on the role of Hox genes, morphogens and interactions with neighbouring tissues in specifying and patterning the skeletogenic NC cells in the head. We also include advances made towards characterizing multipotent stem cells in the early NC as well as in various NC derivatives in embryos and even in adult.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Elisabeth Dupin
    • 1
  • Sophie Creuzet
    • 1
  • Nicole M. Le Douarin
    • 1
  1. 1.Laboratoire d’Embryologie Cellulaire et MoléculaireCNRS UMR 7128Nogent-sur-Marne CedexFrance

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