Metabolism of Acetylcholine: Synthesis and Turnover
According to (1936), the precondition for accepting acetylcholine (ACh) as the cholinergic transmitter is that there should be a way to destroy it or otherwise terminate its action rapidly. The corollary of this concept is that a mechanism must be available for maintaining ACh synthesis during the course of synaptic activity. Lindor Brown and William Feldberg formulated this corollary at the same time. They stated, “If it is true that acetylcholine is liberated by nerve impulse and not synthesized ... by this impulse ... resynthesis must occur at some time if the tissue is to retain its acetylcholine“ (Brown and Feldberg, 1936).
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