Protein Misassembly

Macromolecular Crowding and Molecular Chaperones
  • R. John Ellis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 594)

Abstract

The generic tendency of proteins to misassemble into nonfunctional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This problem is exacerbated by the high total concentration of macromolecules found within most in-tracellular compartments but it is solved by the actions of molecular chaperones. This review discusses some of the basic evidence and key concepts relating to this conclusion.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • R. John Ellis
    • 1
  1. 1.Department of Biological SciencesUniversity of WarwickCoventryUK

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