Protein Misassembly

Macromolecular Crowding and Molecular Chaperones
  • R. John Ellis


The generic tendency of proteins to misassemble into nonfunctional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This problem is exacerbated by the high total concentration of macromolecules found within most in-tracellular compartments but it is solved by the actions of molecular chaperones. This review discusses some of the basic evidence and key concepts relating to this conclusion.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • R. John Ellis
    • 1
  1. 1.Department of Biological SciencesUniversity of WarwickCoventryUK

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