Endosomes pp 62-75 | Cite as

Clathrin Adaptor Proteins in Cargo Endocytosis

  • Linton M. Traub
Chapter
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Eukaryotic cells continuously remodel the protein and lipid composition of the plasma membrane in response to the extracellular milieu. Membrane retrieval typically involves inward budding of small bilayer-encapsulated vesicles that shuttle protein and lipid from the surface to internal endosomal elements. Clathrin-mediated endocytosis is a dominant pathway for internalization in many cell types, and a range of dedicated signals are used to ensure selective sorting in this pathway. Evidence suggests that the clathrin coat utilizes a diverse collection of clathrin-associated sorting proteins (CLASPs) to ensure the efficient and noncompetitive concentration of a wide variety of sorting signals within transport vesicles forming at the cell surface.

Keywords

Coated Vesicle Sorting Signal Clathrin Coat Sensory Organ Precursor Autosomal Recessive Hypercholesterolemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Landes bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Linton M. Traub
    • 1
  1. 1.Department of Cell Biology and PhysiologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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