Biglycan Is a Positive Modulator of BMP-2 Induced Osteoblast Differentiation

  • Yoshiyuki Mochida
  • Duenpim Parisuthiman
  • Mitsuo Yamauchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 585)


Development of the vertebrate skeleton is a complex process involving genes that control a series of cellular events such as proliferation, migration, mesenchymal condensations and eventually differentiation into osteoblasts and chondrocytes1. For osteoblast differentiation, an intricate and highly regulated interplay of growth factors, receptors/co-receptors, specific extracellular milieu and transcription factors is required2. Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF- ) superfamily, are multifunctional growth factors critically involved in osteoblast differentiation. The BMP functions are exerted through their interaction with specific cell surface receptors, BMP type I and II receptors, leading to the regulation of specific BMP target genes. The signaling is regulated at numerous steps at extracellular, cell surface and intracellular levels3, 4.


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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Yoshiyuki Mochida
    • 1
  • Duenpim Parisuthiman
    • 1
  • Mitsuo Yamauchi
    • 1
  1. 1.CB#7455 Dental Research CenterUniversity of North Carolina at Chapel HillUSA

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