Intrinsic Versus Extrinsic Vascularization in Tissue Engineering

  • Elias Polykandriotis
  • Raymund. E. Horch
  • Andreas Arkudas
  • Apostolos Labanaris
  • Kay Brune
  • Peter Greil
  • Alexander D. Bach
  • Jürgen Kopp
  • Andreas Hess
  • Ulrich Kneser
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 585)


In-vitro culture of tissues can be regulated by controlled medium administration whereas ex-vivo bioreactors are designed with the capability of providing tissue engineered devices with continuous nutrient support. When these materials or cellular constructs are transferred in vivo they have to rely on processes like interstitial fluid diffusion and blood perfusion. Here recites a core limitation for transfer of tissue engineering models from the in vitro to the in vivo environment. Diffusion is the initial process involved but it can only provide for cell support within a maximum range of 200 μm into the matrix.1, 2, 3, 4


Tissue Engineering Subcutaneous Implantation Fibrovascular Tissue Isolation Chamber Calcium Phosphate Bone Cement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Elias Polykandriotis
    • 1
  • Raymund. E. Horch
    • 1
  • Andreas Arkudas
    • 1
  • Apostolos Labanaris
    • 1
  • Kay Brune
    • 2
  • Peter Greil
    • 3
  • Alexander D. Bach
    • 1
  • Jürgen Kopp
    • 1
  • Andreas Hess
    • 2
  • Ulrich Kneser
    • 1
  1. 1.Dept. Plastic and Hand SurgeryUniversity of ErlangenGermany
  2. 2.Institute of Pharmacology and ToxicologyUniversity of ErlangenGermany
  3. 3.Institute of Materials Sciences, Dept. Glass and CeramicsUniversity of ErlangenGermany

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