Taurine 6 pp 251-254 | Cite as

Effects of Taurine Supplementation on Cholesterol Levels with Potential Ramification in Atherosclerosis

  • John B. Lombardini
  • Julius D. Militante
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 583)

5. Conclusions

It is quite convincing from the literature that taurine supplemented in the diet and administered to various animal models (rat, mouse, and rabbit) has a significant effect in reducing both total cholesterol and the induced atherogenic lesions. Unfortunately, there are very few studies in which taurine has been administered to humans. Because of the present prevalence of high fat diets in our society and the serious sequellae associated with high serum cholesterol levels, it is considered after reviewing the data in the literature that more studies are needed to access the value of supplemental dietary taurine in the human model. If truly beneficial in lowering human hypercholesterol levels, taurine could be an inexpensive, nontoxic dietary supplement with significant cardiovascular properties.


Bile Acid Gallstone Formation High Cholesterol Diet Atherogenic Index Sodium Cholate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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6. References

  1. Balkan, J., Oztezcan, S., Aykac-Toker, G., and Uysal, M., 2002, Effects of added dietary taurine on erythrocyte lipids and oxidative stress in rabbits fed a high cholesterol diet, Biosci. Biotechnol. Biochem. 66: 2701–2705.PubMedCrossRefGoogle Scholar
  2. Balkan, J., Oztezcan, S., Hatipoglu, A., Cevikbas, U., Aykac-Toker, G., and Uysal, M., 2004, Effect of a taurine treatment on the regression of existing atherosclerotic lesions in Rabbits fed on a high-cholesterol diet. Biosci. Biotechnol. Biochem. 68:1035–1039.PubMedCrossRefGoogle Scholar
  3. Chen, W., Matuda, K., Nishimura, N., and Yokogoshi, H., 2004, The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet. Life Sci. 74:1889–1898.PubMedCrossRefGoogle Scholar
  4. Militante, J. D. and Lombardini, J.B., 2004, Dietary taurine supplementation: hypolipidemic and antiatherogenic effects, Nutr. Res. 24:787–801.CrossRefGoogle Scholar
  5. Nishimura, N., Umeda, C., Oda, H., and Yokogoshi, H., 2003, The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid. J. Nutr. Sci. Vitaminol. (Tokyo), 49:21–26.Google Scholar
  6. Yamori, Y., Murakami, S., Ikeda, K., and Nara Y., 2004, Fish and lifestyle-related disease prevention: experimental and epidemiological evidence for anti-atherogenic potential of taurine. Clin. Exp. Pharmacol. Physiol. 31:S20–S23.PubMedCrossRefGoogle Scholar
  7. Zhang, M., Bi, L. F., Fang, J. H., Su, X. L., Da, G. L., Kuwamori, T., and Kagamimori, S., 2004, Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids 26:267–272.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • John B. Lombardini
    • 1
  • Julius D. Militante
    • 1
  1. 1.Department of PharmacologyTexas Tech University Health Sciences CenterLubbockUSA

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