Taurine 6 pp 193-202 | Cite as

Effects of Taurine on mRNA Levels of Nuclear Receptors and Factors Involved in Cholesterol and Bile Acid Homeostasis in Mice

  • Nien Vinh Lam
  • Wen Chen
  • Kazuhito Suruga
  • Naomichi Nishimura
  • Toshinao Goda
  • Hiroaki Oda
  • Hidehiko Yokogoshi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 583)


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

6. References

  1. Agellon, L. B., Drover, V. A., Cheema, S. K., Gbaguidi, G. F., and Walsh, A., 2002, Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice, J. Biol Chem. 277:20131–20134.PubMedCrossRefGoogle Scholar
  2. Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D. J., and Suchy, F. J., 2001, Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor, J. Biol. Chem. 276:28857–28865.PubMedCrossRefGoogle Scholar
  3. Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J., Kwiterovich, P., Shan, B., Barnes, R., and Hobbs, H. H., 2000, Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters, Science 290:1771–1775.PubMedCrossRefGoogle Scholar
  4. Cantafora, A., Mantovani, A., Masella, R., Mechelli, L., and Alvaro D., 1986, Effect of taurine administration on liver lipids in guinea pig, Experientia 42:407–408.PubMedCrossRefGoogle Scholar
  5. Chen, W., Matuda, K., Nishimura, N., and Yokogoshi, H., 2004, The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet, Life Sci. 74:1889–1998.PubMedCrossRefGoogle Scholar
  6. Chiang, J. Y. L., 1998, Regulation of bile acid synthesis, Front. Biosci. 3:D176–D193.PubMedGoogle Scholar
  7. Chiang, J. Y., 2003, Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors, Am J Physiol. Gastrointest. Liver Physiol. 284:G349–G356.PubMedGoogle Scholar
  8. Crestani, M., Sadeghpour, A., Stroup, D., Galli, G., and Chiang, J. Y., 1998, Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors, J. Lipid Res. 39:2192–2200.PubMedGoogle Scholar
  9. Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M., and Kliewer, S. A., 2000, A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis, Mol. Cell 6:517–526.PubMedCrossRefGoogle Scholar
  10. Grober, J., Zaghini, I., Fujii, H., Jones, S. A., Kliewer, S. A., Willson, T. M., Ono, T., and Besnard, P., 1999, Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer, J. Biol. Chem. 274:29749–29754.PubMedCrossRefGoogle Scholar
  11. Gupta, S., Stravitz, R. T., Dent, P., and Hylemon, P. B., 2001, Down-regulation of cholesterol 7 alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway, J. Biol. Chem. 276:15816–15822.PubMedCrossRefGoogle Scholar
  12. Hagenbuch, B. and Dawson, P., 2004, The sodium bile salt cotransport family SLC10, Pflugers Arch. 447:566–570.PubMedCrossRefGoogle Scholar
  13. Herrmann, R. G., 1959, Effect of taurine, glycine and sitosterols on serum and tissue cholesterol in the rat and rabbit, Circ. Res. 7:224–227.PubMedGoogle Scholar
  14. Huxtable, R. J., 1992, Physiological actions of taurine, Physiol. Rev. 72:101–163.PubMedGoogle Scholar
  15. Li, Y. C. and Chiang, J. Y., 1990, Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA, J. Biol. Chem. 265:12012–12019.PubMedGoogle Scholar
  16. Javitt, N. B., 1994, Bile acid synthesis from cholesterol: regulatory and auxiliary pathways, FASEB J. 8:1308–1311.PubMedGoogle Scholar
  17. Jelinek, D. F. and Russell, D. W., 1990, Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase, Biochemistry 29:7781–7785.PubMedCrossRefGoogle Scholar
  18. Kuriyama, K., 1980, Taurine as a neuromodulator, Fed. Proc. 39:2680–2684.PubMedGoogle Scholar
  19. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M., 1997, Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway, J. Biol. Chem. 272:3137–3140.PubMedCrossRefGoogle Scholar
  20. Lombardini, J. B., 1996, Taurine depletion in the intact animal stimulates in vitro phosphorylation of an approximately 44-kDa protein present in the mitochondrial fraction of the rat heart, J. Mol. Cell. Cardiol. 28:1957–1961.PubMedCrossRefGoogle Scholar
  21. Mochizuki, H., Oda, H., and Yokogoshi, H., 1998, Increasing effect of dietary taurine on the serum HDL-cholesterol concentration in rats, Biosci. Biotechnol. Biochem. 62:578–579.PubMedCrossRefGoogle Scholar
  22. Moundras, C., Behr, S. R., Remesy, C., and Demigne, C., 1997, Fecal losses of sterols and bile acids induced by feeding rats guar gum are due to greater pool size and liver bile acid secretion, J. Nutr. 127:1068–1076.PubMedGoogle Scholar
  23. Murakami, S., Kondo, Y., Toda, Y., Kitajima, H., Kameo, K., Sakono, M., and Fukuda, N., 2002, Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine. Life Sci. 70:2355–2366.PubMedCrossRefGoogle Scholar
  24. Myant, N. B. and Mitropoulos, K. A., 1977, Cholesterol 7 alpha-hydroxylase, J. Lipid Res. 18:135–153.PubMedGoogle Scholar
  25. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., and Nebert, D. W., 1996, P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature, Pharmacogenetics 6:1–42.PubMedCrossRefGoogle Scholar
  26. Nishimura, N., Umeda, C., Oda, H., and Yokogoshi, H., 2003, The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid, J. Nutr. Sci. Vitaminol. (Tokyo) 49:21–26.Google Scholar
  27. Nitta, M., Ku, S., Brown, C., Okamoto, A. Y., and Shan, B., 1999, CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene, Proc. Natl. Acad. Sci. USA 96:6660–6665.PubMedCrossRefGoogle Scholar
  28. Ogishima, T. and Okuda, K., 1986, An improved method for assay of cholesterol 7 alpha-hydroxylase activity, Anal. Biochem. 158:228–232.PubMedCrossRefGoogle Scholar
  29. Pasantes-Morales, H., Wright, C. E., and Gaull, G. E., 1985, Taurine protection of lymphoblastoid cells from iron-ascorbate induced damage, Biochem. Pharmacol. 34:2205–2207.PubMedCrossRefGoogle Scholar
  30. Russell, D. W. and Setchell, K. D., 1992, Bile acid biosynthesis, Biochemistry 31:4737–4749.PubMedCrossRefGoogle Scholar
  31. Sheltawy, M. J. and Losowsky, M. S., 1975, Determination of fecal bile acids by an enzymic method, Clin. Chim. Acta 64:127–132.PubMedCrossRefGoogle Scholar
  32. Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J., 2000, Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis, Cell 102:731–744.PubMedCrossRefGoogle Scholar
  33. Sjovall, J., 2004, Fifty years with bile acids and steroids in health and disease, Lipids 39:703–722.PubMedGoogle Scholar
  34. Stroup, D., Crestani, M., and Chiang, J. Y., 1997, Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A, Am. J. Physiol. 273:G508–G517.PubMedGoogle Scholar
  35. Sturman, J. A., 1993, Taurine in development, Physiol. Rev. 73:119–148.PubMedGoogle Scholar
  36. Thurston, J. H., Hauhart, R. E., and Dirgo, J. A., 1980, Taurine: A role in osmotic regulation of mammalian brain and possible clinical significances, Life Sci. 26:1561–1568.PubMedCrossRefGoogle Scholar
  37. Wright, C. E., Tallan, H. H., and Lin, Y. Y., 1986, Taurine: biological update, Annu. Rev. Biochem. 55:427–453.PubMedCrossRefGoogle Scholar
  38. Yokogoshi, H., Mochizuki, H., Nanami, K., Hida, Y., Miyachi, F., and Oda, H., 1999, Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet, J. Nutr. 129:1705–1712.PubMedGoogle Scholar
  39. Yu, L., Li-Hawkins, J., Hammer, R. E., Berge, K. E., Horton, J. D., Cohen, J.C., and Hobbs, H. H., 2002, Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol, J. Clin. Invest. 110:671–680.PubMedCrossRefGoogle Scholar
  40. Zhang, E. Y., Phelps, M. A., Cheng, C., Ekins, S., and Swaan, P. W., 2002, Modeling of active transport systems, Adv. Drug Deliv. Rev. 54:329–354.PubMedCrossRefGoogle Scholar
  41. Zhang, M., Bi, L. F., Fang, J. H., Su, X. L., Da, G. L., Kuwamori, T., and Kagamimori, S., 2004, Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects, Amino Acids 26:267–271.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Nien Vinh Lam
    • 1
  • Wen Chen
    • 1
  • Kazuhito Suruga
    • 1
  • Naomichi Nishimura
    • 2
  • Toshinao Goda
    • 1
  • Hiroaki Oda
    • 3
  • Hidehiko Yokogoshi
    • 1
  1. 1.University of ShizuokaShizuokaJapan
  2. 2.Nayoro City CollegeNayoroJapan
  3. 3.Nagoya UniversityNagoyaJapan

Personalised recommendations