Molecular Pathology in Clinical Practice

pp 517-531

Assessment of Chimerism in the Setting of Allogeneic Hematopoietic Cell Transplantation

  • Vivianna M. Van DeerlinAffiliated withMolecular Pathology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System
  • , Erica WilliamsAffiliated withDepartment of Legal Medicine and the Office of the Chief Medical Examiner, Virginia Commonwealth University School of Medicine

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Hematopoietic cell transplantation (HCT) has become a well-established treatment option for a variety of malignant and nonmalignant diseases. Molecular analysis of chimerism is used to monitor the levels of donor and recipient cells in patients after HCT. The clinical utility and interpretation of chimerism analysis depend on the type of bone marrow transplant used and the underlying disease. After transplantation, chimerism analysis is used to confirm engraftment of donor hematopoiesis and identify and quantify the percentage of recipient cells to guide patient management aimed at helping to prevent graft failure or relapse.