Identification of the Receptor for FGL2 and Implications for Susceptibility to Mouse Hepatitis Virus (MHV-3)-Induced Fulminant Hepatitis

  • Hao Liu
  • Li Zhang
  • Myron Cybulsky
  • Reg Gorczynski
  • Jennifer Crookshank
  • Justin Manuel
  • David Grant
  • Gary Levy
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)


Fulminant Hepatitis Susceptible Mouse Mouse Hepatitis Virus Vaccinia Virus Vector Endothelial Cell Production 
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  1. 1.
    Marsden, P. A., Ning, Q., Fung, L. S., Luo, X., Chen, Y., Mendicino, M., Ghanekar, A., Scott, J. A., Miller, T., Chan, C. W., Chan, M. W., He, W., Gorczynski, R. M., Grant, D. R., Clark, D. A., Phillips, M. J., Levy, G. A., 2003, The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis, J. Clin. Invest. 112:58-66.PubMedGoogle Scholar
  2. 2.
    Marazzi, S., Blum, S., Hartmann, R., Gundersen, D., Schreyer, M., Argraves, S., von Fliedner, V., Pytela, R., and Ruegg, C., 1998, Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes, J. Immunol. 161:138-147.PubMedGoogle Scholar
  3. 3.
    Herman, A. E., Freeman, G. J., Mathis, D., and Benoist, C., 2004, CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion, J. Exp. Med. 199:1479-1489.CrossRefPubMedGoogle Scholar
  4. 4.
    Chan, C. W., Kay, L. S., Khadaroo, R. G., Chan, M. W., Lakatoo, S., Young, K. J., Zhang, L., Gorczynski, R. M., Cattral, M., Rotstein, O., and Levy, G. A., 2003, Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrowderived dendritic cells, J. Immunol. 170:4036-4044.PubMedGoogle Scholar
  5. 5.
    Schiller, C., Janssen-Graalfs, I., Baumann, U., Schwerter-Strumpf, K., Izui, S., Takai, T., Schmidt, R. E., and Gessner, J. E., 2000, Mouse FcgammaRII is a negative regulator of FcgammaRIII in IgG immune complex-triggered inflammation but not in autoantibody-induced hemolysis, Eur. J. Immunol. 30:481-490.CrossRefPubMedGoogle Scholar
  6. 6.
    Ravetch, J. V., and Kinet, J. P., 1991, Fc receptors, Annu. Rev. Immunol. 9:457-492.PubMedGoogle Scholar
  7. 7.
    Pricop, L., Redecha, P., Teillaud, J. L., Frey, J., Fridman, W. H., Sautes-Fridman, C., and Salmon, J. E., 2001, Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines, J. Immunol. 166:531-537.PubMedGoogle Scholar
  8. 8.
    Oleszak, E. L., Perlman, S., and Leibowitz, J. L., 1992, MHV S peplomer protein expressed by a recombinant vaccinia virus vector exhibits IgG Fc-receptor activity, Virology 186:122-132.CrossRefPubMedGoogle Scholar
  9. 9.
    Johnson, D. C., Frame, M. C., Ligas, M. W., Cross, A. M., and Stow, N. D., 1988, Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI, J. Virol. 62:1347-1354.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Hao Liu
    • 1
  • Li Zhang
    • 2
  • Myron Cybulsky
    • 3
  • Reg Gorczynski
    • 4
  • Jennifer Crookshank
    • 5
  • Justin Manuel
    • 6
  • David Grant
    • 7
  • Gary Levy
    • 8
  1. 1.University of TorontoCanada
  2. 2.University of TorontoCanada
  3. 3.University of TorontoCanada
  4. 4.University of TorontoCanada
  5. 5.University of TorontoCanada
  6. 6.University of TorontoCanada
  7. 7.University of TorontoCanada
  8. 8.University of TorontoCanada

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