Spike Gene Determinants of Mouse Hepatitis Virus Host Range Expansion

  • Willie C. McRoy
  • Ralph S. Baric
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)


Receptor Binding Domain Mouse Hepatitis Virus Spike Glycoprotein Host Range Expansion Murine Coronavirus 
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  1. 1.
    R. S. Baric, et al., Persistent infection promotes cross-species transmissibility of mouse hepatitis virus, J. Virol. 73, 638–649 (1999).PubMedGoogle Scholar
  2. 2.
    W. Chen and R. S. Baric, Molecular anatomy of mouse hepatitis virus persistence: coevolution of increased host cell resistance and virus virulence, J. Virol. 70, 3947–3960 (1996).PubMedGoogle Scholar
  3. 3.
    R. S. Baric, et al., Episodic evolution mediates interspecies transfer of a murine coronavirus, J. Virol. 71, 1946–1955 (1997).PubMedGoogle Scholar
  4. 4.
    J. H. Schickli, et al., The murine coronavirus mouse hepatitis virus strain A59 from persistently infected murine cells exhibits an extended host range, J. Virol. 71, 9499–9507 (1997).PubMedGoogle Scholar
  5. 5.
    L. Kuo, et al., Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier, J. Virol. 74, 1393–1406 (2000).CrossRefPubMedGoogle Scholar
  6. 6.
    B. Yount, et al., Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59, J. Virol. 76, 11065–11078 (2002).CrossRefPubMedGoogle Scholar
  7. 7.
    R. J. de Groot, et al., Evidence for a coiled-coil structure in the spike proteins of coronaviruses, J. Mol. Biol. 196, 963–966 (1987).CrossRefPubMedGoogle Scholar
  8. 8.
    Z. Luo and S. R. Weiss, Roles in cell-to-cell fusion of two conserved hydrophobic regions in the murine coronavirus spike protein, Virology 244, 483–494 (1998).CrossRefPubMedGoogle Scholar
  9. 9.
    P. Chambers, C. R. Pringle, and A. J. Easton, 1990, Heptad repeat sequences are located adjacent to hydrophobic regions in several types of virus fusion glycoproteins, J. Gen. Virol. 71, 3075–3080 (1990).CrossRefPubMedGoogle Scholar
  10. 10.
    J. H. Schickli, et al., The N-terminal region of the murine coronavirus spike glycoprotein is associated with the extended host range of viruses from persistently infected murine cells, J. Virol. 78, 9073–9083 (2004).CrossRefPubMedGoogle Scholar
  11. 11.
    L. B. Thackray and K. V. Holmes, Amino acid substitutions and an insertion in the spike glycoprotein extend the host range of the murine coronavirus MHV-A59, Virology 324, 510–524 (2004).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Willie C. McRoy
    • 1
  • Ralph S. Baric
    • 2
  1. 1.University of North CarolinaChapel HillUSA
  2. 2.University of North CarolinaChapel HillUSA

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