Leptin pp 263-308 | Cite as

Leptin in Farm Animals

  • C. Richard Barb
  • Gary J. Hausman
  • Timothy G. Ramsay
Chapter
Part of the Endocrine Updates book series (ENDO, volume 25)

Abstract:

The Recently discovered protein, leptin, which is secreted by fat cells, has been implicated in regulation of feed intake, energy balance and the neuroendocrine axis in rodents, humans and large domestic animals. The leptin receptor which has been cloned and is a member of the class 1 cytokine family of receptors is found in the brain and pituitary and numerous peripheral tissues. The interaction of leptin in energy metabolism, feed intake regulation, growth and immune function in domestic animals is reviewed. Preadipocyte recruitment and subsequent fat cell size and leptin gene expression are regulated by such hormones as insulin and cortisol and its interactions. Leptin serves as a metabolic signalthat acts on the hypothalamic-pituitary-ovarian axis to enhance GnRH and LH secretion and ovarian function.

Key words

leptin reproduction hormone metabolism nutrition adipocyte 
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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • C. Richard Barb
    • 1
  • Gary J. Hausman
    • 1
  • Timothy G. Ramsay
    • 2
  1. 1.Animal Physiology Research UnitUSDA-ARSAthensGAUSA
  2. 2.Growth Biology LaboratoryUSDA-ARSBeltsvilleUSA

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