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B-Cell Receptor

  • Randall J. Brezski
  • John G. Monroe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 640)

Abstract

The subunit structure of the B-cell antigen receptor (BCR) and its associated compart-mentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes sets these receptors apart from almost all other cell surface signal transduction proteins and affords them the ability to participate in almost all of the diverse aspects of, in this case, B-cell biology. We discuss here the structural aspects of the BCR and its associated coreceptors and relate these mechanistically to how BCR signaling can be directed towards specific fate decisions. By doing so, the BCR plays a pivotal role in ensuring the effective and appropriate B-cell response to antigen.

Keywords

Lipid Raft Antigen Receptor Surrogate Light Chain Antigen Receptor Complex Lymphocyte Antigen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Randall J. Brezski
    • 1
  • John G. Monroe
    • 1
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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