The Coronin Family of Proteins pp 20-30

Part of the Subcellular Biochemistry book series (SCBI, volume 48)

Diversity of WD-Repeat proteins

Abstract

The WD-repeat-containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD-repeat domains are thought to have two common features: the domain folds into a beta propeller; and the domains form a platform without any catalytic activity on which multiple protein complexes assemble reversibly. The fact that these proteins play such key roles in the formation of protein-protein complexes in nearly all the major pathways and organelles unique to eukaryotic cells has two important implications. It supports both their ancient and proto eukaryotic origins and supports a likely association with many genetic diseases.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.BioMolecular Engineering Research Center, College of EngineeringBoston UniversityBostonUSA

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