Genetics of Stress: Gene–Stress Correlation and Interaction

Chapter

Abstract

In this chapter, we review two recent developments in behavioral genetics that bear on the determinants and sequelae of psychological stress. The first addresses genetic influences on exposure to environmental stressors (gene–stress correlation), and the second, the moderation of genetic effects on behavioral and biological phenotypes by stress-related environmental variation (gene–stress interaction). There is now abundant evidence of genetic influence on stressful life events, traumatic experiences, and parenting and early family environments, as well as on stress-protective factors such as social support and networks of social engagement. With respect to gene–stress interactions, preliminary evidence suggests that polymorphic variation in genes of plausible mechanism modulates physiological reactions to acute psychological stressors and variably affects more distal outcomes (e.g., hypertension, posttraumatic stress disorder, aggressive conduct) as a function of exposure to early or recent life stressors. However, failures to confirm at least one prominently reported finding in this literature raise concern regarding the replicability of published gene–stress interactions. In concluding, we consider the implications of pervasive gene–stress correlation for the interpretation of gene–stress interaction and discuss conceptual and methodological issues relating to the selection of candidate genes and environmental moderators.

Notes

Acknowledgments

Preparation of this manuscript was supported, in part, by National Institutes of Health Grants PO1 HL040962 and RO1 HL065137 (SBM), and UO1 DK056993, RO1 AG018384, and RO1 HL072819 (JMM).

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Behavioral Physiology Laboratory, Department of PsychologyUniversity of PittsburghPittsburghUSA
  2. 2.Weight Control and Diabetes Research Center, Brown Medical School and The Miriam HospitalProvidenceUSA

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