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Vitamin E Improves Clinical Outcome of Patients Affected by Glycogen Storage Disease Type Ib

  • Daniela MelisEmail author
  • Giorgia Minopoli
  • Francesca Balivo
  • Paola Marcolongo
  • Rossella Parini
  • Sabrina Paci
  • Carlo Dionisi-Vici
  • Roberto Della Casa
  • Angelo Benedetti
  • Generoso Andria
  • Giancarlo Parenti
Research Report
Part of the JIMD Reports book series (JIMD, volume 25)

Abstract

Background: It has been suggested, on a few GSD1b patients, that vitamin E improves neutrophil count and reduces frequency and severity of infections.

The main objective of the present study was to investigate the efficacy of vitamin E on the neutropenia, neutrophil dysfunction and IBD in the entire Italian caseload of GSD1b patients.

Patients and methods: Eighteen GSD1b patients, median age at the time of the study protocol 14.5 (range, 0.6–42 years), were enrolled from four Italian referral centres for metabolic diseases. For the evaluation of the efficacy of vitamin E, neutrophil count and function, frequency of infections needing hospitalization and inflammatory bowel activity were evaluated periodically all over one year before and during vitamin E therapy.

Results: Frequency (1.5 ± 0.1 vs. 6.0 ± 0.6, p = 0.003) and severity of infections (2.2 ± 0.2 vs. 3.7 ± 0.4, p = 0.003) were lower and mean value of neutrophil count (1,583 ± 668 vs. 941 ± 809, p = 0.03) higher during vitamin E supplementation. Neutrophil function results improved during vitamin supplementation. PCDAI showed a significant reduction in the inflammatory activity during vitamin E supplementation (9 ± 1.4 vs. 13 ± 1.2, p = 0.006). In seven patients G-CSF requirement decreased and the dose was reduced after the end of the study.

In conclusion, our study demonstrated the efficacy of vitamin E supplementation. Vitamin E has evident advantages as compared to G-CSF, as it can be assumed orally, and it has not been associated with severe side effects.

Keywords

Antioxidant IBD Infection severity score Neutropenia Neutrophil dysfunction Vitamin E 

Notes

Acknowledgement

The study was partially supported by the Italian Agency of Drugs (AIFA). Study protocol n. FARM5S3JT5

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Copyright information

© SSIEM and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Daniela Melis
    • 1
    Email author
  • Giorgia Minopoli
    • 1
  • Francesca Balivo
    • 1
  • Paola Marcolongo
    • 2
  • Rossella Parini
    • 3
  • Sabrina Paci
    • 4
  • Carlo Dionisi-Vici
    • 5
  • Roberto Della Casa
    • 6
  • Angelo Benedetti
    • 2
  • Generoso Andria
    • 6
  • Giancarlo Parenti
    • 6
    • 7
  1. 1.Dipartimento di PediatriaUniversità “Federico II”NaplesItaly
  2. 2.Dipartimento di BiologiaUniversità degli Studi di SienaSienaItaly
  3. 3.Ospedale S. GerardoMonzaItaly
  4. 4.Ospedale S. PaoloMilanItaly
  5. 5.Ospedale Pediatrico Bambino GesùRomeItaly
  6. 6.Dipartimento di Scienze Mediche Traslazionali, Sezione di PediatriaUniversità degli Studi “Federico II”NaplesItaly
  7. 7.Telethon Institute of Genetics and MedicineNaplesItaly

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