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Lung Parenchyma Remodelling in the Acute Respiratory Distress Syndrome

  • A. B. Souza-Fernandes
  • P. R. M. Rocco
  • W. A. Zin

Abstract

The acute respiratory distress syndrome (ARDS) is a catastrophic condition with exudation, inflammation and often fibrosis throughout the lung [1]. Interestingly, despite the extensive damage, it can be fully repaired [2]. This recovery requires the resolution of inflammation, clearance of inflammatory cells and oedema and reversal of fibrosis, allowing the lung tissue to return to its normal structure and function. The repair process is very complex and modulated not only by several growth factors and cytokines released in the alveolar space during lung injury, but also by a variety of components of the extracellular matrix (ECM) [3].

Keywords

Acute Lung Injury Idiopathic Pulmonary Fibrosis Acute Respiratory Distress Syndrome Elastic Fibre Respir Crit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • A. B. Souza-Fernandes
    • 1
  • P. R. M. Rocco
    • 1
  • W. A. Zin
    • 2
  1. 1.Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of BiophysicsFederal University of Rio de JaneiroRio de JaneiroBrazil
  2. 2.Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of BiophysicsFederal University of Rio de JaneiroRio de JaneiroBrazil

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