Computational Modeling of Mass Transport and Its Relation to Cell Behavior in Tissue Engineering Constructs

  • Dennis Lambrechts
  • Jan Schrooten
  • Tom Van de Putte
  • Hans Van Oosterwyck
Chapter
First Online:
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 10)

Abstract

Effective recapitulation of extracellular matrix properties into a Tissue Engineering strategy is strongly involved with the need for a proper transport environment. Consumption and production of soluble medium components gives rise to gradients which influence cell behavior in various ways. Understanding how transport related phenomena can shape these gradients is targeted in this chapter by the combined use of experiments and mathematical modeling. An overview of different models is given that describe solute transport and its relation to specific cell behavior. From the simulation results important information can be extracted which help to unravel mechanisms that drive solute transport. Finally we describe the genuine efforts that have been taken to translate this information into real tissue engineering setups (e.g., optimization of culture conditions and controlled-release of growth factors).

Keywords

Vascular Endothelial Growth Factor Oxygen Tension Solute Transport Oxygen Uptake Rate Fluorescence Recovery After Photobleaching 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Dennis Lambrechts
    • 1
    • 2
  • Jan Schrooten
    • 1
    • 2
  • Tom Van de Putte
    • 3
  • Hans Van Oosterwyck
    • 2
    • 4
  1. 1.Department of Metallurgy and Materials EngineeringKU LeuvenLeuvenBelgium
  2. 2.Prometheus, Division of Skeletal Tissue Engineering LeuvenKU LeuvenLeuvenBelgium
  3. 3.TiGenix NVHaasrode Researchpark 1724LeuvenBelgium
  4. 4.Biomechanics SectionKU LeuvenLeuvenBelgium

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