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C-Type Lectin Receptors in Phagocytosis

  • Kai Li
  • David M. UnderhillEmail author
Part of the Current Topics in Microbiology and Immunology book series


C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRγ), that mediates signaling. Many CLRs directly recognize microbial cell walls and influence innate immunity by activating inflammatory and antimicrobial responses in phagocytes. In this review, we examine the contributions of certain CLRs to activation and regulation of phagocytosis in cells such as macrophages, dendritic cells and neutrophils.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Division of Immunology, Department of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesUSA

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