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Does Biotechnology Pose New Catastrophic Risks?

  • Diane DiEuliis
  • Andrew D. Ellington
  • Gigi Kwik Gronvall
  • Michael J. ImperialeEmail author
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 424)

Abstract

Advances in biotechnology in the twenty-first century, fueled in large part by the field of synthetic biology, have greatly accelerated capabilities to manipulate and re-program bacteria, viruses, and other organisms. These genetic engineering capabilities are driving innovation and progress in drug manufacturing, bioremediation, and tissue engineering, as well as biosecurity preparedness. However, biotechnology is largely dual use, holding the potential of misuse for deliberate harm along with positive applications; defenses against those threats need to be anticipated and prepared. This chapter describes the challenges of managing dual-use capabilities enabled by modern biotechnology and synthetic biology and highlights a framework tool developed by a National Academies committee to aid analysis of the security effects of new scientific discoveries and prioritization of concerns. The positive aspects of synthetic biology in preparedness are also detailed, and policy directions are highlighted for taking advantage of the positive aspects of these emerging technologies while minimizing risks.

References

  1. Asokan A, Samulski RJ (2013) An emerging adeno-associated viral vector pipeline for cardiac gene therapy. Hum Gene Ther 24(11):906–913CrossRefGoogle Scholar
  2. Cello J, Paul AV, Wimmer E (2002) Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template. Science 297(5583):1016–1018CrossRefGoogle Scholar
  3. Chyba C, Austin W (2016) PCAST letter to the president on action needed to protect against biological attack. President’s Council of Advisors on Science and Technology (PCAST)Google Scholar
  4. Courbet A, Renard E, Molina F (2016) Bringing next-generation diagnostics to the clinic through synthetic biology. EMBO Mol Med 8(9):987–991CrossRefGoogle Scholar
  5. Gibson DG, Glass JI, Lartigue C et al (2010) Creation of a bacterial cell controlled by a chemically synthesized genome. Science 329(5987):52–56CrossRefGoogle Scholar
  6. Goins WF, Hall B, Cohen JB, Glorioso JC (2016) Retargeting of herpes simplex virus (HSV) vectors. Curr Opin Virol 21:93–101CrossRefGoogle Scholar
  7. Inglesby T (2018) The problem of horsepox synthesis: new approaches needed for oversight and publication review for research posing population-level risks. The Bifurcated Needle 2018Google Scholar
  8. Jackson SA, Kralj JG, Lin NJ (2018) Report on the NIST/DHS/FDA workshop: standards for pathogen detection for biosurveillance and clinical applications. NIST (6 Apr 2018)Google Scholar
  9. Kennedy D (2005) Better never than late. Science 310(5746):195CrossRefGoogle Scholar
  10. Koblentz GD (2018) A critical analysis of the scientific and commercial rationales for the De Novo synthesis of Horsepox Virus. mSphere 3(2)Google Scholar
  11. Kouadio KI, Clement P, Bolongei J, et al (2015) Epidemiological and surveillance response to Ebola virus disease outbreak in Lofa County, Liberia (Mar–Sept 2014); Lessons Learned. PLoS Curr 7Google Scholar
  12. Kupferschmidt K (2018) Critics see only risks, no benefits in horsepox paper. Science 359(6374):375–376CrossRefGoogle Scholar
  13. McMullan LK, Flint M, Chakrabarti A et al (2018) Characterisation of infectious Ebola virus from the ongoing outbreak to guide response activities in the Democratic Republic of the Congo: a phylogenetic and in vitro analysis. The Lancet Infect DisGoogle Scholar
  14. National Academies of Sciences, Engineering, and Medicine (2018) Biodefense in the age of synthetic biology. The National Academies Press, Washington, DCGoogle Scholar
  15. National Academies of Sciences, Engineering, and Medicine, Division on Engineering et al (2018) Biodefense in the age of synthetic biology. National Academies Press (US), Washington (DC). Copyright 2018 by the National Academy of Sciences. All rights reservedGoogle Scholar
  16. National Research Council (U.S.) (2004) Committee on research standards and practices to prevent the destructive application of biotechnology. Biotechnol Res Age Terrorism (National Academies Press, Washington, DC)Google Scholar
  17. Neumann G, Watanabe T, Ito H, Watanabe S, Goto H, Gao P, Hughes M, Perez DR, Donis R, Hoffmann E, Hobom G, Kawaoka Y (1999) Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci USA 96(16):9345–9350CrossRefGoogle Scholar
  18. Noyce RS, Lederman S, Evans DH (2018) Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments. PLoS One 13(1):e0188453 (2018)CrossRefGoogle Scholar
  19. Patel P (2016) Paper diagnostic tests could save thousands of lives. Sci AmGoogle Scholar
  20. Schoch-Spana M, Cicero A, Adalja A et al (2017) Global catastrophic biological risks: toward a working definition. Health Secur 15(4):323–328CrossRefGoogle Scholar
  21. Tumpey TM, Basler CF, Aguilar PV et al (2005) Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310(5745):77–80CrossRefGoogle Scholar
  22. van Tongeren SP, Roest HIJ, Degener JE, Harmsen HJM (2014) Bacillus anthracis-like bacteria and other B. cereus group members in a microbial community within the international space station: a challenge for rapid and easy molecular detection of virulent B. anthracis. PLOS ONE 9(6):e98871CrossRefGoogle Scholar
  23. Venkateswaran K, Singh NK, Sielaff AC et al (2017) Non-toxin-producing Bacillus cereus strains belonging to the B. anthracis clade isolated from the international space station. mSystems 2(3):e00021–00017Google Scholar
  24. Venter JC, Gibson D (2010) How we created the first synthetic cell. The Wall Street J (Opinion) (26 May 2010)Google Scholar
  25. Warrick J (2006) Washington post staff W. custom-built pathogens raise bioterror fears: FINAL Edition. The Washington Post. Newspaper Article A.1Google Scholar
  26. Wertz GW, Perepelitsa VP, Ball LA (1998) Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus. Proc Natl Acad Sci U S A 95(7):3501–3506CrossRefGoogle Scholar
  27. Wimmer E (2006) The test-tube synthesis of a chemical called poliovirus. EMBO reports 7(SI):S3–S9CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Diane DiEuliis
    • 1
  • Andrew D. Ellington
    • 2
  • Gigi Kwik Gronvall
    • 3
  • Michael J. Imperiale
    • 4
    Email author
  1. 1.National Defense UniversityWashington, D.C.USA
  2. 2.University of Texas at AustinAustinUSA
  3. 3.Johns Hopkins Center for Health Security, Department of Environmental Health and EngineeringJohns Hopkins University Bloomberg School of Public HealthBaltimoreUSA
  4. 4.Department of Microbiology and ImmunologyUniversity of MichiganAnn ArborUSA

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