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Roles of Non-coding RNAs During Herpesvirus Infection

  • Meaghan H. Hancock
  • Rebecca L. SkalskyEmail author
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 419)

Abstract

Non-coding RNAs (ncRNAs) play essential roles in multiple aspects of the life cycles of herpesviruses and contribute to lifelong persistence of herpesviruses within their respective hosts. In this chapter, we discuss the types of ncRNAs produced by the different herpesvirus families during infection, some of the cellular ncRNAs manipulated by these viruses, and the overall contributions of ncRNAs to the viral life cycle, influence on the host environment, and pathogenesis.

Abbreviations

KSHV

Kaposi’s sarcoma associated herpesvirus

HVS

Herpesvirus saimiri

HCMV

Human Cytomegalovirus

RhCMV

Rhesus Cytomegalovirus

MCMV

Mouse Cytomegalovirus

RCMV

Rat Cytomegalovirus

EBV

Epstein Barr virus

LCV

Lymphocryptovirus

HSV

Herpes simplex virus

miRNA

MicroRNA

snoRNA

Small nucleolar RNA

sisRNA

Stable intronic sequence RNA

ncRNA

Non-coding RNA

EBERs

EBV-encoded RNAs

BARTs

BamHI A rightward transcripts

BHRF1

BamHI right forward 1

PAN

Polyadenylated nuclear RNA

LAT

Latency-associated transcript

HSURs

HVS Sm class U RNAs

UTR

Untranslated region

LMP

Latent membrane protein

RTA

Replication and transcription activator protein

EBNA

EBV nuclear antigen

RNA

Ribonucleic acid

RISC

RNA-induced silencing complex

PAR-CLIP

Photoactivatable ribonucleoside enhanced cross-linking and immunoprecipitation

HITS-CLIP

High throughput sequencing of RNA isolated by cross-linking and immunoprecipitation

ChIRP

Chromatin isolation by RNA purification

CHART

Capture hybridization analysis of RNA targets

TF

Transcription factor

Notes

Acknowledgements

We thank the past and present members of Jay Nelson’s laboratory at VGTI for discussions, and apologize to the many scientists whose work we could not mention due to space limitations. This work was supported by a Pathway to Independence Award CA175181 from the National Cancer Institute to R.L.S. Support for M.H. comes from NIH grant AI21640.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Vaccine and Gene Therapy Institute at Oregon Health and Science UniversityBeavertonUSA

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