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Central Tolerance Induction

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Thymic Development and Selection of T Lymphocytes

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 373))

Abstract

A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has been rapid progress in our understanding of how autoreactive T cell specificities are diverted into the T regulatory lineage. Here we review and highlight the recent progress in how tolerance is imposed on the developing thymocyte repertoire.

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Acknowledgments

This work was supported by the NIH, The Helmsley Charitable Trust, and The Burroughs Wellcome Fund. The authors have no conflict of interest to disclose.

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Authors and Affiliations

  1. Diabetes Center, University of California-San Francisco, Box 0540, San Francisco, CA, 94143, USA

    Maria L. Mouchess & Mark Anderson

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  1. Maria L. Mouchess
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  2. Mark Anderson
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Correspondence to Mark Anderson .

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Editors and Affiliations

  1. Department of Developmental Immunology, Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany

    Thomas Boehm

  2. Institute for Genome Research, Division of Experimental Immunology, University of Tokushima, Tokushima, Japan

    Yousuke Takahama

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Mouchess, M.L., Anderson, M. (2013). Central Tolerance Induction. In: Boehm, T., Takahama, Y. (eds) Thymic Development and Selection of T Lymphocytes. Current Topics in Microbiology and Immunology, vol 373. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_321

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