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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 365))

Abstract

The pandemic H1N1 influenza that began in Mexico in the spring of 2009 spread rapidly to southern California within days and around the world within a few months. Because the genetic make-up of the new virus was novel, several months of lead-in time were required before a suitable vaccine for human use could be produced and distributed. The effort to confront the virus on the part of the World Health Organization which included almost every nation on earth and a vast array of scientists and public health officials was extensive and timely. However, it was the moderate severity of the virus itself that saved global public health from catastrophe. Because of the extensive publicity and research that occurred during the H1N1 pandemic, many lessons were learned that will be useful in confronting future influenza pandemics. A “One Health” approach to prevent, detect, and combat future pandemics is essential.

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References

  • Abelin A, Colegate T, Gardner S, Hehme N, Palache A (2011) Lessons from pandemic influenza A(H1N1): the research-based vaccine industry’s perspective. Vaccine 29:1135–1138

    Article  PubMed  Google Scholar 

  • Australian Government, Department of Health and Ageing (2011) Review of Australia’s health sector response to pandemic (H1N1) 2009: lessons identified. http://www.flupandemic.gov.au/internet/panflu/publishing.nsf. Accessed 26 Nov 2012

  • Blakeley DE (2007) Mass mediated disease: a case study analysis of three flu pandemics and public health policy. Lexington Books, Lanham

    Google Scholar 

  • Briand S, Mounts A, Chamberland M (2011) Challenges of global surveillance during an influenza pandemic. World Health Organization, Global Influenza Programme, Geneva. http://www.who.int/influenza/surveillance_monitoring/Challenges_global_surveillance.pdf. Accessed 19 Nov 2012

  • Brockwell-Staats C, Webster RG, Webby RJ (2009) Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1). Influenza Other Respi Viruses 3:207–213

    Article  Google Scholar 

  • Cantey PT, Chuk MG, Kohl KS, Herrmann J, Weiss P, Graffunder CM, Averhoff F, Kahn EB, Painter J (2013) Public health emergency preparedness: lessons learned about monitoring of interventions from the national association of county and city health official’s survey of nonpharmaceutical interventions for pandemic H1N1. J Public Health Manag Pract 19:70–76

    Google Scholar 

  • Cheng VC, To KK, Tse H, Hung IF, Yuen KY (2012) Two years after pandemic influenza A/2009/H1N1: what have we learned? Clin Microbiol Rev 25:223–263

    Article  PubMed  CAS  Google Scholar 

  • Cohen J (2009a) Swine flu outbreak. flu researchers train sights on novel tricks of novel H1N1. Science 324:870–871

    Article  PubMed  CAS  Google Scholar 

  • Cohen J (2009b) Swine flu outbreak. Past pandemics provide mixed clues to H1N1′s next moves. Science 324:996–997

    Article  PubMed  CAS  Google Scholar 

  • Cohen J (2009c) Pandemic influenza. Straight from the pig’s mouth: swine research with swine influenzas. Science 325:140–141

    Article  PubMed  CAS  Google Scholar 

  • Copeland DL, Basurto-Davila R, Chung W, Kurian A, Fishbein DB, Szymanowski P, Zipprich J, Lipman H, Cetron MS, Meltzer MI, Averhoff F (2012) Effectiveness of a school district closure for pandemic influenza A(H1N1) on acute respiratory illnesses in the community: a natural experiment. Clin Infect Dis (Epub ahead of print) Oct 19. doi:10.1093/cid/cis890

  • Cowling BJ, Zhou Y, Ip DK, Leung GM, Aiello AE (2010) Face masks to prevent transmission of influenza virus: a systematic review. Epidemiol Infect 138:449–456

    Article  PubMed  CAS  Google Scholar 

  • Croston G (2012) The real story of risk: adventures in a hazardous world. Prometheus Books, New York

    Google Scholar 

  • Dorjee S, Poljak Z, Revie CW, Bridgland J, McNab B, Leger E, Sachez J (2012) A review of simulation modelling approaches used for the spread of zoonotic influenza viruses in animal and human populations. Zoonoses Public Health (Epub ahead of print) Sept 3. doi:10.1111/zph.12010

  • Ducatez MF, Hause B, Stigger-Rosser E, Darnell D, Corzo C, Juleen K, Simonson R, Brockwell-Staats C, Rubrum A, Wang D, Webb A, Crumpton JC, Lowe J, Gramer M, Webby RJ (2011) Multiple Reassortment between Pandemic (H1N1) 2009 and Endemic Influenza Viruses in Pigs, United States. Emerg Infect Dis 17:1624–1629

    PubMed  Google Scholar 

  • Fisher D, Hui DS, Gao Z, Lee C, Oh MD, Cao B, Hien TT, Patlovich K, Farrar J (2011) Pandemic response lessons from influenza H1N1 2009 in Asia. Respirology 16:876–882

    Article  PubMed  Google Scholar 

  • Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier RA, Pappas C, Alpuche-Aranda CM, López-Gatell H, Olivera H, López I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ (2009) Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 325:197–201

    Article  PubMed  CAS  Google Scholar 

  • Gendon luZ, Vasil’ev luM (2012) Epidemiologic and economic effectiveness of school closures during influenza epidemics and pandemics [article in Russian]. Zh Mikrobiol Epidemiol Immunobiol 3:113–123

    PubMed  Google Scholar 

  • Girard MP, Tam JS, Assossou OM, Kieny MP (2010) The 2009 A (H1N1) influenza virus pandemic: a review. Vaccine 28:4895–4902

    Article  PubMed  Google Scholar 

  • Girard MP, Katz JM, Pervikov Y, Hombach J, Tam JS (2011) Report of the 7th meeting on evaluation of pandemic influenza vaccines in clinical trials, World Health Organization, Geneva, 17–18 Feb 2011. Vaccine 29:7579–7586

    Google Scholar 

  • Grant KA, Fielding JE, Mercer GN, Carcione D, Lopez L, Smith DW, Huang QS, Kelly HA (2012) Comparison of the pandemic H1N1 2009 experience in the Southern Hemisphere with pandemic expectations. Aust NZ J Publ Heal 36:364–368

    Article  Google Scholar 

  • Hashim A, Jean-Giles L, Hegermann-Lindencrone M, Shaw I, Brown C, Nguyen-Van-Tam J (2012) Did pandemic preparedness aid the response to pandemic (H1N1) 2009? a qualitative analysis in seven countries within the WHO European region. J Infect Public Health 5:286–296

    Article  PubMed  Google Scholar 

  • Hause BM, Collin EA, Ran Z, Zhu L, Webby RJ, Simonson RR, Li F (2012) In vitro reassortment between endemic H1N2 and 2009 H1N1 pandemic swine influenza viruses generates attenuated viruses. PLoS One 7:e39177

    Google Scholar 

  • Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, Li C, Kawakami E, Yamada S, Kiso M, Suzuki Y, Maher EA, Neumann G, Kawaoka Y (2012) Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486:420–428

    PubMed  CAS  Google Scholar 

  • Keller C, Siegrist M, Gutscher H (2006) The role of the affect and availability heuristics in risk communication. Risk Anal 26:631–639

    Article  PubMed  Google Scholar 

  • Lam TT, Zhu H, Wang J, Smith DK, Holmes EC, Webster RG, Webby R, Peiris JM, Guan Y (2011) Reassortment events among swine influenza a viruses in China: implications for the origin of the 2009 influenza pandemic. J Virol 85:10279–10295

    Article  PubMed  CAS  Google Scholar 

  • LaRussa P (2011) Pandemic novel 2009 H1N1 influenza: what have we learned? Semin Respir Crit Care Med 32:393–399

    Article  PubMed  Google Scholar 

  • Leider JP, Brunker PA, Ness PM (2010) Convalescent transfusion for pandemic influenza: preparing blood banks for a new plasma product? Transfusion 50:1384–1398

    Article  PubMed  Google Scholar 

  • Leung GM, Nicoll A (2010) Reflections on pandemic (H1N1) 2009 and the international response. PLoS Med 7:e1000346

    Article  PubMed  Google Scholar 

  • Lipsitch M, Finelli L, Heffernan RT, Leung GM, Redd SC (2011) H1N1 Surveillance group improving the evidence base for decision making during a pandemic: the example of 2009 influenza A/H1N1. Biosecur Bioterror 9:89–115

    PubMed  Google Scholar 

  • Liu Q, Ma J, Liu H, Qi W, Anderson J, Henry SC, Hesse RA, Richt JA, Ma W (2012). Emergence of novel reassortant H3N2 swine influenza viruses with the 2009 pandemic H1N1 genes in the United States. Arch Virol 157:555–562

    Article  PubMed  CAS  Google Scholar 

  • Ma W, Kahn RE, Richt JA (2008). The pig as a mixing vessel for influenza viruses: human and veterinary implications. J Mol Genet Med 3:158–166

    PubMed  Google Scholar 

  • Ma W, Lager KM, Vincent AL, Janke BH, Gramer MR, Richt JA (2009) The role of swine in the generation of novel influenza viruses. Zoonoses Public Health 56:326–327

    Article  PubMed  CAS  Google Scholar 

  • Ma W, Richt JA (2010) Swine influenza vaccines: current status and future perspectives. Anim Health Res Rev 11:81–96

    Article  PubMed  Google Scholar 

  • McCaw JM, McVernon J (2012) Defining pandemic impact levels to guide proportionate and flexible operational response to the next influenza pandemic—modelling studies to guide Australia’s pandemic policy development. Poster presented to the conference: Incidence, severity and impact. Munich, Germany, Sept 2012. http://mathmodelling.sph.unimelb.edu.au/posters/McCaw-ISIRV_Munich_2012.pdf. Accessed 1 Dec 2012

  • McVernon J, McCaw JM, Nolan TM (2010) Modelling strategic use of the national antiviral stockpile during the CONTAIN and SUSTAIN phases of an Australian pandemic influenza response. Aust N Z J Public Health 34:113–119

    Article  PubMed  Google Scholar 

  • Morikane K (2010) Changing management of pandemic influenza [Article in Japanese]. Rinsho Byori 58:254–262

    PubMed  Google Scholar 

  • Moss R, McCaw JM, McVernon J (2011) Diagnosis and antiviral intervention strategies for mitigating an influenza epidemic. PLoS One 6:e14505

    Article  PubMed  CAS  Google Scholar 

  • Neustadt RE, Fineberg HV (2005) The swine flu affair: decision-making on a slippery disease. University Press of the Pacific, Honolulu

    Google Scholar 

  • Prati G, Pietrantoni L, Zani B (2011) A social-cognitive model of pandemic influenza H1N1 risk perception and recommended behaviors in Italy. Risk Anal 31:645–656

    Article  PubMed  Google Scholar 

  • Quinn T (2008) Flu: a social history of influenza. New Holland Publishers, London

    Google Scholar 

  • Rudenko L, van den Bosch H, Kiseleva I, Mironov A, Naikhin A, Larionova N, Bushmenkov D (2011) Live attenuated pandemic influenza vaccine: clinical studies on A/17/California/2009/38 (H1N1) and licensing of the Russian-developed technology to WHO for pandemic influenza preparedness in developing countries. Vaccine Suppl 1(29):A40–44

    Google Scholar 

  • Schnitzler SU, Schnitzler P (2009) An update on swine-origin influenza virus A/H1N1: a review. Virus Genes 39:279–292

    Article  PubMed  CAS  Google Scholar 

  • Schuchat A, Bell BP, Redd SC (2011) The science behind preparing and responding to pandemic influenza: the lessons and limits of science. Clin Infect Dis 52 (Suppl 1):S8–12

    Article  PubMed  Google Scholar 

  • Shapshak P, Chiappelli F, Somboonwit C, Sinnott J (2011) The influenza pandemic of 2009: lessons and implications. Mol Diagn Ther 15:63–81

    Article  PubMed  Google Scholar 

  • Silverstein AM (1981) Pure politics and impure science: the swine flu affair. Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Sinha NK, Roy A, Das B, Das S, Basak S (2009) Evolutionary complexities of swine flu H1N1 gene sequences of 2009. Biochem Biophys Res Commun 18:390(3):349–351

    Google Scholar 

  • Slovic P, Finucane ML, Peters E, MacGregor DG (2004) Risk as analysis and risk as feelings: Some thoughts about affect, reason, risk, and rationality. Risk Anal 24:311–322

    Article  PubMed  Google Scholar 

  • SteelFisher GK, Blendon RJ, Ward JR, Rapoport R, Kahn EB, Kohl KS (2012) Public response to the 2009 influenza A H1N1 pandemic: a polling study in five countries. Lancet Infect Dis 12:845–850

    Article  PubMed  Google Scholar 

  • Swedish KA, Conenello G, Factor SH (2010) First Season of 2009 H1N1 Influenza. Mt Sinai J Med 77:103–113

    Article  PubMed  Google Scholar 

  • Van Kerkhove MD, Ferguson NM (2012) Epidemic and intervention modelling—a scientific rationale for policy decisions? Lessons from the 2009 influenza pandemic. Bull World Health Organ 90:245-320. http://www.who.int/bulletin/volumes/90/4/11-097949/en/index.html. Accessed 1 Dec 2012

  • Van Kerkhovel MD, Vandemaelel KAH, Shindel V, Jaramillo-Gutierrez G, Koukounari A, Donnelly C, Carlino LO, Owen R, Paterson B, Pelletier L, Vachon J, Gonzalez C, Hongjie Y, Zijian F, Chuang SK, Au A, Buda S, Krause G, Haas W, Bonmarin I, Taniguichi K, Nakajima K, Shobayashi T, Takayama Y, Sunagawa T, Heraud JM, Orelle A, Palacios E, van der Sande MAB, Wielders CCHL, Hunt D, Cutter J, Lee V, Thomas J, Santa-Olalla P, Sierra-Moros MJ, Hanshaoworakul W, Ungchusak K, Pebody R, Jain S, Mounts AW (2011) Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. Appeal PMEDICINE-D-10-00373. http://www.who.int/influenza/surveillance_monitoring/Risk_factors_H1N1.pdf. Accessed 1 Dec 2012

  • Van Reeth K, Ma W (2012) Swine influenza virus vaccines: to change or not to change—that’s the question. Curr Top Microbiol Immunol Sept 13. (Epub ahead of print). doi:10.1007/82_2012.266

    Google Scholar 

  • Viasus D, Cordero E, Rodriguez-Baño J, Oteo, JA, Fernández-Navarro A, Ortega L, Gracia-Ahufinger I, Fariñas MC, Garcia-Almodovar E, Payeras A, Paño-Pardo JR, Muñez-Rubio E, Carratalà J, Novel Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI) (2012) Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season. Clin Microbiol Infect 18:E55–E62

    Google Scholar 

  • Webby R, Richt JA (2013) Influenza in Swine. In: Webster RG, Monto AS, Braciale TJ, Lamb RA (eds) Textbook of influenza, 2nd edn. Wiley-Blackwell, Hoboken (in press)

    Google Scholar 

  • World Health Organization (2010) Evolution of a pandemic a (H1N1) 2009, April 2009–March 2010. http://whqlibdoc.who.int/publications/2010/9789241599924_eng.pdf. Accessed 1 Dec 2012

  • World Health Organization (2011a) Weekly epidemiological record, 27 May 2011, No 22, vol 86, pp 226–227. http://www.who.int/wer/2011/wer8622.pdf. Accessed 1 Dec 2012

  • World Health Organization (2011b) Public health measures during the influenza A(H1N1) 2009 pandemic. Meeting Report 26–28 Oct 2010, Gammarth, Tunisia. http://whqlibdoc.who.int/hq/2011/WHO_HSE_GIP_ITP_2011.3_eng.pdf. Accessed 1 Dec 2012

  • World Health Organization (2011c) Pandemic influenza preparedness framework for the sharing of influenza virus and access to vaccines and other benefits. ISBN 978 92 4 150308 2. http://who.int/influenza/resources/pip_framework/en/index.html. Accessed 1 Dec 2012

  • World Health Organization (2012a) Weekly epidemiological record, 12 October 2012, No. 41, vol 87, pp 389–400. http://www.who.int/wer/2012/wer8741.pdf. Accessed 1 Dec 2012

  • World Health Organization (2012b) Special issue of the Bulletin on Influenza in the twenty first Century. vol 90, pp 245–320. http://www.who.int/influenza/resources/publications/Bulletin/en/index.html. Accessed 1 Dec 2012

  • Wu P, Cowling BJ, Wu JT, Lau EH, Ip DK, Nishiura H (2012) The epidemiological and public health research response to 2009 pandemic influenza A(H1N1): experiences from Hong Kong. Influenza Other Respi Viruses, Aug 9 (Epub ahead of print). doi:10.1111.1750-2659.2012.004120x

  • Xue Y, Kristiansen IS, de Blasio BF (2012) Dynamic modelling of costs and health consequences of school closures during an influenza pandemic. BMC Public Health 12:962

    Google Scholar 

  • York I, Donis RO (2012) The 2009 pandemic influenza virus: where did it come from, where is it now, and where is it going. Curr Top Microbiol Immunol, May 26 (Epub ahead of print). doi:10.1007.82_2012_221

    Google Scholar 

  • Zhu H, Webby R, Lam TT, Smith DK, Peiris JS, Guan Y (2011) History of swine influenza viruses in Asia. Curr Top Microbiol Immunol, Sept 23. (Epub ahead of print). doi:10.1007/82-_2011_179

    Google Scholar 

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Acknowledgments

The authors are grateful to Chris Miller and the Kansas State University librarians for their assistance in obtaining numerous relevant articles. The project was partially funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract number HHSN266200700005C, by U. S. Department of Homeland Security under Grant Award Number 2010-ST061-AG0001, and by the Kansas Bioscience Authority. The authors declare that they have no competing interests.

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Richt, J.A., Webby, R.J., Kahn, R.E. (2013). The Pandemic H1N1 Influenza Experience. In: Mackenzie, J., Jeggo, M., Daszak, P., Richt, J. (eds) One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. Current Topics in Microbiology and Immunology, vol 365. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_309

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