Systems Biology of Vaccination in the Elderly

  • Sai S. Duraisingham
  • Nadine Rouphael
  • Mary M. Cavanagh
  • Helder I. Nakaya
  • Jorg J. Goronzy
  • Bali PulendranEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 363)


Aging population demographics, combined with suboptimal vaccine responses in the elderly, make the improvement of vaccination strategies in the elderly a developing public health issue. The immune system changes with age, with innate and adaptive cell components becoming increasingly dysfunctional. As such, vaccine responses in the elderly are impaired in ways that differ depending on the type of vaccine (e.g., live attenuated, polysaccharide, conjugate, or subunit) and the mediators of protection (e.g., antibody and/or T cell). The rapidly progressing field of systems biology has been shown to be useful in predicting immunogenicity and offering insights into potential mechanisms of protection in young adults. Future application of systems biology to vaccination in the elderly may help to identify gene signatures that predict suboptimal responses and help to identify more accurate correlates of protection. Moreover, the identification of specific defects may be used to target novel vaccination strategies that improve efficacy in elderly populations.


Influenza Vaccination System Biology Approach Yellow Fever Virus Vaccine Response Innate Immune Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The work in the laboratory of B.P. was supported by grants U19AI090023, HHSN266200700006C, U54AI057157, R37AI48638, R37DK057665, U19AI057266, and NO1 AI50025 from the National Institutes of Health and a grant from the Bill & Melinda Gates Foundation.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Sai S. Duraisingham
    • 1
  • Nadine Rouphael
    • 2
  • Mary M. Cavanagh
    • 3
  • Helder I. Nakaya
    • 1
  • Jorg J. Goronzy
    • 3
    • 4
  • Bali Pulendran
    • 1
    Email author
  1. 1.Emory Vaccine Center, Yerkes National Primate Research CenterEmory UniversityAtlantaUSA
  2. 2.Division of Infectious Diseases, Department of MedicineEmory University School of MedicineAtlantaUSA
  3. 3.Department of MedicineStanford UniversityStanfordUSA
  4. 4.Department of MedicinePalo Alto Veteran Administration Health Care SystemPalo AltoUSA

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